ENSMUSG00000030934


Mus musculus

Features
Gene ID: ENSMUSG00000030934
  
Biological name :Oat
  
Synonyms : Oat / ornithine aminotransferase / P29758
  
Possible biological names infered from orthology : P04181
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 132557478
Gene end: 132576398
  
Corresponding Affymetrix probe sets: 10568568 (MoGene1.0st)   1416452_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147794
Ensembl peptide - ENSMUSP00000081544
NCBI entrez gene - 18242     See in Manteia.
MGI - MGI:97394
RefSeq - NM_016978
RefSeq Peptide - NP_058674
swissprot - A0A1B0GS50
swissprot - P29758
swissprot - Q3TG75
Ensembl - ENSMUSG00000030934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oatENSDARG00000078425Danio rerio
 OATENSGALG00000031158Gallus gallus
 OATENSG00000065154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005814  Aminotransferase class-III
 IPR010164  Ornithine aminotransferase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR034758  Ornithine aminotransferase, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0055129 L-proline biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004587 ornithine-oxo-acid transaminase activity ISO
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IBA
 molecular_functionGO:0042802 identical protein binding IBA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129 * C57BL/6J

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008581 disorganized photoreceptor inner segment "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oattm1Dva/Oattm1Dva
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Oatrhg/Oatrhg
Genetic Background: B6Ei;AKR-Oatrhg/J

 MP:0011765 oroticaciduria "increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine" [MGI:anna]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030934 Oat / P29758 / ornithine aminotransferase / P04181*  / complex






 

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