ENSMUSG00000031154


Mus musculus

Features
Gene ID: ENSMUSG00000031154
  
Biological name :Otud5
  
Synonyms : Otud5 / OTU domain-containing protein 5 / Q3U2S4
  
Possible biological names infered from orthology : OTU deubiquitinase 5 / Q96G74
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 7841364
Gene end: 7876626
  
Corresponding Affymetrix probe sets: 10598456 (MoGene1.0st)   1435573_at (Mouse Genome 430 2.0 Array)   1436262_x_at (Mouse Genome 430 2.0 Array)   1438985_x_at (Mouse Genome 430 2.0 Array)   1453865_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111332
Ensembl peptide - ENSMUSP00000111329
Ensembl peptide - ENSMUSP00000111330
Ensembl peptide - ENSMUSP00000111331
Ensembl peptide - ENSMUSP00000033494
NCBI entrez gene - 54644     See in Manteia.
MGI - MGI:1859615
RefSeq - XM_017318564
RefSeq - NM_001290536
RefSeq - NM_001290537
RefSeq - NM_138604
RefSeq - XM_006527664
RefSeq - XM_006527665
RefSeq - XM_006527666
RefSeq - XM_006527667
RefSeq Peptide - NP_613070
RefSeq Peptide - NP_001277465
RefSeq Peptide - NP_001277466
swissprot - A2AES3
swissprot - Q3U2S4
swissprot - A2AES4
swissprot - A2AES5
Ensembl - ENSMUSG00000031154
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otud5aENSDARG00000059006Danio rerio
 otud5bENSDARG00000056840Danio rerio
 OTUD5ENSG00000068308Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otud4 / B2RRE7 / OTU domain-containing protein 4 / Q01804* / OTU deubiquitinase 4*ENSMUSG0000003699014


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain
 IPR031084  OTU domain-containing protein 5/Otubain-like deubiquitinase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0070536 protein K63-linked deubiquitination ISS
 biological_processGO:0071108 protein K48-linked deubiquitination ISS
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 biological_processGO:0072607 interleukin-9 secretion IMP
 biological_processGO:0072619 interleukin-21 secretion IMP
 biological_processGO:1905077 negative regulation of interleukin-17 secretion IMP
 biological_processGO:2000316 regulation of T-helper 17 type immune response IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity ISO
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity ISO
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008711 increased interleukin-9 secretion "increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0009057 increased interleukin-21 secretion "increase in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Anxa10em1Siag/Anxa10+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Otud5tm1Vmd/Otud5tm1Vmd,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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