ENSMUSG00000031189


Mus musculus

Features
Gene ID: ENSMUSG00000031189
  
Biological name :Aff2
  
Synonyms : AF4/FMR2 family member 2 / Aff2 / O55112
  
Possible biological names infered from orthology : P51816
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.1
Gene start: 69360294
Gene end: 69868037
  
Corresponding Affymetrix probe sets: 10599927 (MoGene1.0st)   1422116_at (Mouse Genome 430 2.0 Array)   1458014_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033532
NCBI entrez gene - 14266     See in Manteia.
MGI - MGI:1202294
RefSeq - XM_006527821
RefSeq - NM_008032
RefSeq - XM_006527819
RefSeq - XM_006527820
RefSeq - XM_006527816
RefSeq - XM_006527817
RefSeq - XM_006527818
RefSeq Peptide - NP_032058
swissprot - O55112
Ensembl - ENSMUSG00000031189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aff2ENSDARG00000052242Danio rerio
 AFF2ENSGALG00000009168Gallus gallus
 AFF2ENSG00000155966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aff3 / AF4/FMR2 family member 3 / P51826*ENSMUSG0000003713837
Aff4 / Q9ESC8 / AF4/FMR2 family member 4 / Q9UHB7*ENSMUSG0000004947033
Aff1 / AF4/FMR2 family member 1 / P51825*ENSMUSG0000002931327


Protein motifs (from Interpro)
Interpro ID Name
 IPR007797  Transcription factor AF4/FMR2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0035063 nuclear speck organization ISO
 biological_processGO:0043484 regulation of RNA splicing IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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