ENSMUSG00000049470


Mus musculus

Features
Gene ID: ENSMUSG00000049470
  
Biological name :Aff4
  
Synonyms : AF4/FMR2 family member 4 / Aff4 / Q9ESC8
  
Possible biological names infered from orthology : Q9UHB7
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 53350833
Gene end: 53421830
  
Corresponding Affymetrix probe sets: 10375980 (MoGene1.0st)   1420912_at (Mouse Genome 430 2.0 Array)   1450031_at (Mouse Genome 430 2.0 Array)   1458959_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120613
Ensembl peptide - ENSMUSP00000051479
Ensembl peptide - ENSMUSP00000118866
NCBI entrez gene - 93736     See in Manteia.
MGI - MGI:2136171
RefSeq - XM_006534560
RefSeq - XM_011249331
RefSeq - NM_033565
RefSeq Peptide - NP_291043
swissprot - Q9ESC8
swissprot - F6WNE9
swissprot - B7ZC42
Ensembl - ENSMUSG00000049470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aff4ENSDARG00000001857Danio rerio
 AFF4ENSGALG00000030147Gallus gallus
 AFF4ENSG00000072364Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aff1 / AF4/FMR2 family member 1 / P51825*ENSMUSG0000002931339
Aff2 / O55112 / AF4/FMR2 family member 2 / P51816*ENSMUSG0000003118936
Aff3 / AF4/FMR2 family member 3 / P51826*ENSMUSG0000003713835


Protein motifs (from Interpro)
Interpro ID Name
 IPR007797  Transcription factor AF4/FMR2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007286 spermatid development IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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