ENSMUSG00000029313


Mus musculus

Features
Gene ID: ENSMUSG00000029313
  
Biological name :Aff1
  
Synonyms : AF4/FMR2 family member 1 / Aff1
  
Possible biological names infered from orthology : P51825
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 103692374
Gene end: 103855322
  
Corresponding Affymetrix probe sets: 10523647 (MoGene1.0st)   10523670 (MoGene1.0st)   1418135_at (Mouse Genome 430 2.0 Array)   1425640_at (Mouse Genome 430 2.0 Array)   1425641_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031256
Ensembl peptide - ENSMUSP00000119631
Ensembl peptide - ENSMUSP00000059744
NCBI entrez gene - 17355     See in Manteia.
MGI - MGI:1100819
RefSeq - XM_006534801
RefSeq - NM_001080798
RefSeq - NM_133919
RefSeq Peptide - NP_598680
RefSeq Peptide - NP_001074267
swissprot - E9Q921
swissprot - A3KMF4
swissprot - B1AVP1
Ensembl - ENSMUSG00000029313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AFF1ENSGALG00000043935Gallus gallus
 AFF1ENSG00000172493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aff4 / Q9ESC8 / AF4/FMR2 family member 4 / Q9UHB7*ENSMUSG0000004947036
Aff3 / AF4/FMR2 family member 3 / P51826*ENSMUSG0000003713830
Aff2 / O55112 / AF4/FMR2 family member 2 / P51816*ENSMUSG0000003118928


Protein motifs (from Interpro)
Interpro ID Name
 IPR007797  Transcription factor AF4/FMR2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0008023 transcription elongation factor complex IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aff1tm1Cim/Aff1tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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