ENSMUSG00000037138


Mus musculus

Features
Gene ID: ENSMUSG00000037138
  
Biological name :Aff3
  
Synonyms : AF4/FMR2 family member 3 / Aff3
  
Possible biological names infered from orthology : P51826
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 38177326
Gene end: 38664955
  
Corresponding Affymetrix probe sets: 10354111 (MoGene1.0st)   1430435_at (Mouse Genome 430 2.0 Array)   1433939_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116289
Ensembl peptide - ENSMUSP00000148461
Ensembl peptide - ENSMUSP00000044128
Ensembl peptide - ENSMUSP00000092637
NCBI entrez gene - 16764     See in Manteia.
MGI - MGI:106927
RefSeq - XM_011238447
RefSeq - NM_001290814
RefSeq - XM_006495737
RefSeq - XM_011238443
RefSeq - XM_011238444
RefSeq - XM_011238446
RefSeq Peptide - NP_001277743
swissprot - D6RHR2
swissprot - F8WJA7
swissprot - D3YYI6
swissprot - A0A1D5RLQ3
Ensembl - ENSMUSG00000037138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aff3ENSDARG00000079575Danio rerio
 ENSGALG00000016767Gallus gallus
 ENSGALG00000031502Gallus gallus
 AFF3ENSG00000144218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aff2 / O55112 / AF4/FMR2 family member 2 / P51816*ENSMUSG0000003118938
Aff4 / Q9ESC8 / AF4/FMR2 family member 4 / Q9UHB7*ENSMUSG0000004947033
Aff1 / AF4/FMR2 family member 1 / P51825*ENSMUSG0000002931330


Protein motifs (from Interpro)
Interpro ID Name
 IPR007797  Transcription factor AF4/FMR2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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