ENSMUSG00000031700


Mus musculus

Features
Gene ID: ENSMUSG00000031700
  
Biological name :Gpt2
  
Synonyms : glutamic pyruvate transaminase (alanine aminotransferase) 2 / Gpt2 / Q8BGT5
  
Possible biological names infered from orthology : glutamic--pyruvic transaminase 2 / Q8TD30
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 85492576
Gene end: 85527560
  
Corresponding Affymetrix probe sets: 10573626 (MoGene1.0st)   1434542_at (Mouse Genome 430 2.0 Array)   1438385_s_at (Mouse Genome 430 2.0 Array)   1439029_at (Mouse Genome 430 2.0 Array)   1455007_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115968
Ensembl peptide - ENSMUSP00000034136
NCBI entrez gene - 108682     See in Manteia.
MGI - MGI:1915391
RefSeq - NM_173866
RefSeq Peptide - NP_776291
swissprot - D6RFQ8
swissprot - Q8BGT5
Ensembl - ENSMUSG00000031700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpt2ENSDARG00000012199Danio rerio
 GPT2ENSGALG00000033338Gallus gallus
 GPT2ENSG00000166123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpt / Q8QZR5 / glutamic pyruvic transaminase, soluble / P24298* / glutamic--pyruvic transaminase*ENSMUSG0000002254663


Protein motifs (from Interpro)
Interpro ID Name
 IPR004839  Aminotransferase, class I/classII
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006103 2-oxoglutarate metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0042851 L-alanine metabolic process IEA
 biological_processGO:0042853 L-alanine catabolic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004021 L-alanine:2-oxoglutarate aminotransferase activity ISO
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

 MP:0013242 abnormal amino acid metabolism "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Agtpbp1pcd-9J/Agtpbp1pcd-9J,Batf2tm1Kmm/Batf2tm1Kmm
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031700 Gpt2 / Q8BGT5 / glutamic pyruvate transaminase (alanine aminotransferase) 2 / Q8TD30* / glutamic--pyruvic transaminase 2*  / complex






 

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