ENSMUSG00000031948


Mus musculus

Features
Gene ID: ENSMUSG00000031948
  
Biological name :Kars
  
Synonyms : Kars / Lysine--tRNA ligase / Q99MN1
  
Possible biological names infered from orthology : lysyl-tRNA synthetase / Q15046
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111993443
Gene end: 112011323
  
Corresponding Affymetrix probe sets: 10581940 (MoGene1.0st)   1416068_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034426
Ensembl peptide - ENSMUSP00000090808
Ensembl peptide - ENSMUSP00000126268
Ensembl peptide - ENSMUSP00000148790
NCBI entrez gene - 85305     See in Manteia.
MGI - MGI:1934754
RefSeq - XM_017313031
RefSeq - NM_001130868
RefSeq - NM_001286384
RefSeq - NM_053092
RefSeq - XM_006531519
RefSeq Peptide - NP_444322
RefSeq Peptide - NP_001273313
RefSeq Peptide - NP_001124340
swissprot - A0A1D5RMI3
swissprot - Q8R2P8
swissprot - Q3TIV6
swissprot - Q99MN1
Ensembl - ENSMUSG00000031948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 karsENSDARG00000103799Danio rerio
 KARSENSGALG00000000907Gallus gallus
 KARSENSG00000065427Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002313  Lysine-tRNA ligase, class II
 IPR004364  Aminoacyl-tRNA synthetase, class II (D/K/N)
 IPR004365  OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018149  Lysyl-tRNA synthetase, class II, C-terminal
 IPR034762  Bacterial/eukaryotic lysine-tRNA ligase, class II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0002276 basophil activation involved in immune response ISO
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response ISO
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006430 lysyl-tRNA aminoacylation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis ISO
 biological_processGO:0015966 diadenosine tetraphosphate biosynthetic process ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0043032 positive regulation of macrophage activation ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0070371 ERK1 and ERK2 cascade ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response ISO
 biological_processGO:1900745 positive regulation of p38MAPK cascade ISO
 biological_processGO:1905050 positive regulation of metallopeptidase activity ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017101 aminoacyl-tRNA synthetase multienzyme complex IDA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003877 ATP adenylyltransferase activity ISO
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004824 lysine-tRNA ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr