ENSMUSG00000031967


Mus musculus

Features
Gene ID: ENSMUSG00000031967
  
Biological name :Afg3l1
  
Synonyms : Afg3l1 / AFG3-like protein 1 / Q920A7
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 123477903
Gene end: 123503916
  
Corresponding Affymetrix probe sets: 10576354 (MoGene1.0st)   1418336_at (Mouse Genome 430 2.0 Array)   1449045_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001520
Ensembl peptide - ENSMUSP00000095924
NCBI entrez gene - 114896     See in Manteia.
MGI - MGI:1928277
RefSeq - XM_011248276
RefSeq - NM_054070
RefSeq Peptide - NP_473411
swissprot - Q920A7
Ensembl - ENSMUSG00000031967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-174d20.2ENSDARG00000079651Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*ENSMUSG0000002452769
Spg7 / Q3ULF4 / Paraplegin / Q9UQ90* / SPG7, paraplegin matrix AAA peptidase subunit*ENSMUSG0000000073832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000642  Peptidase M41
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005936  Peptidase, FtsH
 IPR011546  Peptidase M41, FtsH extracellular
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037219  Peptidase M41-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007005 mitochondrion organization IGI
 biological_processGO:0008053 mitochondrial fusion IGI
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0034982 mitochondrial protein processing IGI
 biological_processGO:0042407 cristae formation IGI
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005745 m-AAA complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
Show

Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0012023 decreased melanocyte number "reduced number of the cells that produce pigment" [MGI:llw2]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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