ENSMUSG00000000738


Mus musculus

Features
Gene ID: ENSMUSG00000000738
  
Biological name :Spg7
  
Synonyms : Paraplegin / Q3ULF4 / Spg7
  
Possible biological names infered from orthology : Q9UQ90 / SPG7, paraplegin matrix AAA peptidase subunit
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 123062942
Gene end: 123097760
  
Corresponding Affymetrix probe sets: 10576191 (MoGene1.0st)   1427166_a_at (Mouse Genome 430 2.0 Array)   1441585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119017
Ensembl peptide - ENSMUSP00000133602
Ensembl peptide - ENSMUSP00000120793
Ensembl peptide - ENSMUSP00000120361
Ensembl peptide - ENSMUSP00000119552
Ensembl peptide - ENSMUSP00000104496
Ensembl peptide - ENSMUSP00000115039
Ensembl peptide - ENSMUSP00000118066
NCBI entrez gene - 234847     See in Manteia.
MGI - MGI:2385906
RefSeq - NM_153176
RefSeq Peptide - NP_694816
swissprot - A0A1I7Q4C2
swissprot - F6VTG4
swissprot - F6W695
swissprot - G3UX97
swissprot - D3Z342
swissprot - Q3ULF4
swissprot - D3YZN4
swissprot - D3YXB7
Ensembl - ENSMUSG00000000738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spg7ENSDARG00000068187Danio rerio
 SPG7ENSGALG00000028363Gallus gallus
 SPG7ENSG00000197912Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*ENSMUSG0000002452733
Afg3l1 / Q920A7 / AFG3-like protein 1 ENSMUSG0000003196733


Protein motifs (from Interpro)
Interpro ID Name
 IPR000642  Peptidase M41
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR005936  Peptidase, FtsH
 IPR011546  Peptidase M41, FtsH extracellular
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037219  Peptidase M41-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0030155 regulation of cell adhesion TAS
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005745 m-AAA complex IDA
 cellular_componentGO:0005757 mitochondrial permeability transition pore complex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004264 Phb2 / O35129 / Prohibitin-2 / Q99623*  / complex
 ENSMUSG00000029017 Pmpcb / Q9CXT8 / peptidase (mitochondrial processing) beta / O75439* / peptidase, mitochondrial processing beta subunit*  / reaction
 ENSMUSG00000038845 Phb / P67778 / Prohibitin / P35232*  / complex
 ENSMUSG00000022452 Smdt1 / Q9DB10 / single-pass membrane protein with aspartate rich tail 1 / Q9H4I9*  / reaction / complex
 ENSMUSG00000025971 Maip1 / Q8BHE8 / m-AAA protease-interacting protein 1, mitochondrial / Q8WWC4* / matrix AAA peptidase interacting protein 1*  / complex
 ENSMUSG00000024527 Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*  / complex






 

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