ENSMUSG00000029017


Mus musculus

Features
Gene ID: ENSMUSG00000029017
  
Biological name :Pmpcb
  
Synonyms : peptidase (mitochondrial processing) beta / Pmpcb / Q9CXT8
  
Possible biological names infered from orthology : O75439 / peptidase, mitochondrial processing beta subunit
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 21737141
Gene end: 21757152
  
Corresponding Affymetrix probe sets: 10520010 (MoGene1.0st)   1429709_at (Mouse Genome 430 2.0 Array)   1433729_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119619
Ensembl peptide - ENSMUSP00000122278
Ensembl peptide - ENSMUSP00000030882
NCBI entrez gene - 73078     See in Manteia.
MGI - MGI:1920328
RefSeq - NM_028431
RefSeq Peptide - NP_082707
swissprot - Q9CXT8
swissprot - D3Z1T9
swissprot - F7BPA5
Ensembl - ENSMUSG00000029017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pmpcbENSDARG00000016979Danio rerio
 PMPCBENSGALG00000008280Gallus gallus
 PMPCBENSG00000105819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CZ13 / Uqcrc1 / ubiquinol-cytochrome c reductase core protein 1 / P31930*ENSMUSG0000002565153


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IBA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006627 protein processing involved in protein targeting to mitochondrion IEA
 biological_processGO:0009060 aerobic respiration IBA
 biological_processGO:0016485 protein processing IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005750 mitochondrial respiratory chain complex III IBA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0017087 mitochondrial processing peptidase complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025971 Maip1 / Q8BHE8 / m-AAA protease-interacting protein 1, mitochondrial / Q8WWC4* / matrix AAA peptidase interacting protein 1*  / reaction
 ENSMUSG00000000738 Spg7 / Q3ULF4 / Paraplegin / Q9UQ90* / SPG7, paraplegin matrix AAA peptidase subunit*  / reaction
 ENSMUSG00000022452 Smdt1 / Q9DB10 / single-pass membrane protein with aspartate rich tail 1 / Q9H4I9*  / reaction
 ENSMUSG00000038845 Phb / P67778 / Prohibitin / P35232*  / reaction
 ENSMUSG00000024527 Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*  / reaction
 ENSMUSG00000004264 Phb2 / O35129 / Prohibitin-2 / Q99623*  / reaction
 ENSMUSG00000026926 Pmpca / Q9DC61 / peptidase (mitochondrial processing) alpha / Q10713* / peptidase, mitochondrial processing alpha subunit*  / complex






 

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