ENSMUSG00000022452


Mus musculus

Features
Gene ID: ENSMUSG00000022452
  
Biological name :Smdt1
  
Synonyms : Q9DB10 / single-pass membrane protein with aspartate rich tail 1 / Smdt1
  
Possible biological names infered from orthology : Q9H4I9
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 82338959
Gene end: 82349091
  
Corresponding Affymetrix probe sets: 10425757 (MoGene1.0st)   1452584_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125429
Ensembl peptide - ENSMUSP00000155835
Ensembl peptide - ENSMUSP00000155174
Ensembl peptide - ENSMUSP00000023086
Ensembl peptide - ENSMUSP00000125120
NCBI entrez gene - 69029     See in Manteia.
MGI - MGI:1916279
RefSeq - NM_026914
RefSeq Peptide - NP_081190
swissprot - E0CZF0
swissprot - E0CXP9
swissprot - Q9DB10
Ensembl - ENSMUSG00000022452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smdt1aENSDARG00000095826Danio rerio
 smdt1bENSDARG00000098852Danio rerio
 SMDT1ENSGALG00000011897Gallus gallus
 SMDT1ENSG00000183172Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018782  Essential MCU regulator, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IEA
 biological_processGO:0036444 calcium import into the mitochondrion IEA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IEA
 cellular_componentGO:1990246 uniplex complex IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Mitochondrial calcium ion transport
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004264 Phb2 / O35129 / Prohibitin-2 / Q99623*  / complex / reaction
 ENSMUSG00000024527 Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*  / reaction / complex
 ENSMUSG00000025971 Maip1 / Q8BHE8 / m-AAA protease-interacting protein 1, mitochondrial / Q8WWC4* / matrix AAA peptidase interacting protein 1*  / complex / reaction
 ENSMUSG00000029017 Pmpcb / Q9CXT8 / peptidase (mitochondrial processing) beta / O75439* / peptidase, mitochondrial processing beta subunit*  / reaction
 ENSMUSG00000038845 Phb / P67778 / Prohibitin / P35232*  / reaction / complex
 ENSMUSG00000000738 Spg7 / Q3ULF4 / Paraplegin / Q9UQ90* / SPG7, paraplegin matrix AAA peptidase subunit*  / complex / reaction






 

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