ENSMUSG00000004264


Mus musculus

Features
Gene ID: ENSMUSG00000004264
  
Biological name :Phb2
  
Synonyms : O35129 / Phb2 / Prohibitin-2
  
Possible biological names infered from orthology : Q99623
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 124712336
Gene end: 124716950
  
Corresponding Affymetrix probe sets: 10541711 (MoGene1.0st)   1416202_at (Mouse Genome 430 2.0 Array)   1438938_x_at (Mouse Genome 430 2.0 Array)   1455713_x_at (Mouse Genome 430 2.0 Array)   1460035_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004375
Ensembl peptide - ENSMUSP00000119316
Ensembl peptide - ENSMUSP00000121535
NCBI entrez gene - 12034     See in Manteia.
MGI - MGI:102520
RefSeq - NM_007531
RefSeq Peptide - NP_031557
swissprot - Q3V235
swissprot - F6Q8V7
swissprot - F6QPR1
swissprot - O35129
Ensembl - ENSMUSG00000004264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phb2aENSDARG00000045297Danio rerio
 phb2bENSDARG00000017728Danio rerio
 PHB2ENSGALG00000014567Gallus gallus
 PHB2ENSG00000215021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000163  Prohibitin
 IPR001107  Band 7 domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0031536 positive regulation of exit from mitosis IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060744 mammary gland branching involved in thelarche IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0033218 amide binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001933 abnormal litter size "deviation from the normal number of live born pups in a litter" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Phb2tm1Katz/Phb2tm1Katz
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Phb2tm2.1Katz/Phb2tm2.1Katz,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022452 Smdt1 / Q9DB10 / single-pass membrane protein with aspartate rich tail 1 / Q9H4I9*  / complex / reaction
 ENSMUSG00000004264 Phb2 / O35129 / Prohibitin-2 / Q99623*  / complex
 ENSMUSG00000000738 Spg7 / Q3ULF4 / Paraplegin / Q9UQ90* / SPG7, paraplegin matrix AAA peptidase subunit*  / complex
 ENSMUSG00000024527 Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*  / complex
 ENSMUSG00000025971 Maip1 / Q8BHE8 / m-AAA protease-interacting protein 1, mitochondrial / Q8WWC4* / matrix AAA peptidase interacting protein 1*  / complex
 ENSMUSG00000029017 Pmpcb / Q9CXT8 / peptidase (mitochondrial processing) beta / O75439* / peptidase, mitochondrial processing beta subunit*  / reaction
 ENSMUSG00000038845 Phb / P67778 / Prohibitin / P35232*  / complex






 

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