ENSMUSG00000038845


Mus musculus

Features
Gene ID: ENSMUSG00000038845
  
Biological name :Phb
  
Synonyms : P67778 / Phb / Prohibitin
  
Possible biological names infered from orthology : P35232
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 95666957
Gene end: 95680773
  
Corresponding Affymetrix probe sets: 10380551 (MoGene1.0st)   10422776 (MoGene1.0st)   1417053_at (Mouse Genome 430 2.0 Array)   1448563_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047536
Ensembl peptide - ENSMUSP00000119603
NCBI entrez gene - 18673     See in Manteia.
MGI - MGI:97572
RefSeq - NM_008831
RefSeq Peptide - NP_032857
swissprot - P67778
swissprot - Q5SQG5
Ensembl - ENSMUSG00000038845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phbENSDARG00000057414Danio rerio
 PHBENSGALG00000038604Gallus gallus
 PHBENSG00000167085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000163  Prohibitin
 IPR001107  Band 7 domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001552 ovarian follicle atresia IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045917 positive regulation of complement activation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0031315 extrinsic component of mitochondrial outer membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001850 complement component C3a binding IEA
 molecular_functionGO:0001851 complement component C3b binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031871 proteinase activated receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004902 abnormal uterus size "anomaly in the size of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009088 thin uterine horn "reduced thickness of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009091 endometrium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: PhbGt(BGB069)Byg/PhbGt(BGB069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029017 Pmpcb / Q9CXT8 / peptidase (mitochondrial processing) beta / O75439* / peptidase, mitochondrial processing beta subunit*  / reaction
 ENSMUSG00000025971 Maip1 / Q8BHE8 / m-AAA protease-interacting protein 1, mitochondrial / Q8WWC4* / matrix AAA peptidase interacting protein 1*  / complex
 ENSMUSG00000022452 Smdt1 / Q9DB10 / single-pass membrane protein with aspartate rich tail 1 / Q9H4I9*  / complex / reaction
 ENSMUSG00000024527 Afg3l2 / Q8JZQ2 / AFG3-like protein 2 / Q9Y4W6* / AFG3 like matrix AAA peptidase subunit 2*  / complex
 ENSMUSG00000004264 Phb2 / O35129 / Prohibitin-2 / Q99623*  / complex
 ENSMUSG00000000738 Spg7 / Q3ULF4 / Paraplegin / Q9UQ90* / SPG7, paraplegin matrix AAA peptidase subunit*  / complex
 ENSMUSG00000038845 Phb / P67778 / Prohibitin / P35232*  / complex






 

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