ENSG00000167085


Homo sapiens

Features
Gene ID: ENSG00000167085
  
Biological name :PHB
  
Synonyms : P35232 / PHB / prohibitin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.33
Gene start: 49404049
Gene end: 49414905
  
Corresponding Affymetrix probe sets: 200658_s_at (Human Genome U133 Plus 2.0 Array)   200659_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393320
Ensembl peptide - ENSP00000407828
Ensembl peptide - ENSP00000484113
Ensembl peptide - ENSP00000479488
Ensembl peptide - ENSP00000426433
Ensembl peptide - ENSP00000425035
Ensembl peptide - ENSP00000422182
Ensembl peptide - ENSP00000410680
Ensembl peptide - ENSP00000300408
NCBI entrez gene - 5245     See in Manteia.
OMIM - 176705
RefSeq - XM_017024763
RefSeq - NM_001281496
RefSeq - NM_001281497
RefSeq - NM_001281715
RefSeq - NM_002634
RefSeq - XM_017024762
RefSeq Peptide - NP_001268644
RefSeq Peptide - NP_002625
RefSeq Peptide - NP_001268425
RefSeq Peptide - NP_001268426
swissprot - C9JW96
swissprot - A8K401
swissprot - E7ESE2
swissprot - D6RBK0
swissprot - C9JZ20
swissprot - P35232
swissprot - E9PCW0
Ensembl - ENSG00000167085
  
Related genetic diseases (OMIM): 114480 - {Breast cancer, susceptibility to}, 114480
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phbENSDARG00000057414Danio rerio
 PHBENSGALG00000038604Gallus gallus
 PhbENSMUSG00000038845Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000163  Prohibitin
 IPR001107  Band 7 domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport TAS
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010942 positive regulation of cell death IGI
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IDA
 biological_processGO:0016575 histone deacetylation IDA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045917 positive regulation of complement activation IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0050847 progesterone receptor signaling pathway IDA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071354 cellular response to interleukin-6 IDA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001850 complement component C3a binding IDA
 molecular_functionGO:0001851 complement component C3b binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031871 proteinase activated receptor binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
RAF activation
Signaling by moderate kinase activity BRAF mutants
Signaling by RAS mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105819 PMPCB / O75439 / peptidase, mitochondrial processing beta subunit  / reaction
 ENSG00000162972 MAIP1 / Q8WWC4 / matrix AAA peptidase interacting protein 1  / complex
 ENSG00000167085 PHB / P35232 / prohibitin  / complex
 ENSG00000141385 AFG3L2 / Q9Y4W6 / AFG3 like matrix AAA peptidase subunit 2  / complex
 ENSG00000197912 SPG7 / Q9UQ90 / SPG7, paraplegin matrix AAA peptidase subunit  / complex
 ENSG00000183172 SMDT1 / Q9H4I9 / single-pass membrane protein with aspartate rich tail 1  / complex / reaction
 ENSG00000215021 PHB2 / Q99623 / prohibitin 2  / complex






 

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