ENSGALG00000038604


Gallus gallus

Features
Gene ID: ENSGALG00000038604
  
Biological name :PHB
  
Synonyms : P84173 / PHB / Prohibitin
  
Possible biological names infered from orthology : P35232 / P67778
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 3579366
Gene end: 3585028
  
Corresponding Affymetrix probe sets: Gga.5534.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060591
Ensembl peptide - ENSGALP00000061263
Ensembl peptide - ENSGALP00000047091
Ensembl peptide - ENSGALP00000048291
Ensembl peptide - ENSGALP00000050951
NCBI entrez gene - 419980     See in Manteia.
RefSeq - NM_001177735
RefSeq Peptide - NP_001171206
swissprot - A0A1L1RP67
swissprot - P84173
Ensembl - ENSGALG00000038604
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phbENSDARG00000057414Danio rerio
 PHBENSG00000167085Homo sapiens
 PhbENSMUSG00000038845Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000163  Prohibitin
 IPR001107  Band 7 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045917 positive regulation of complement activation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001850 complement component C3a binding IEA
 molecular_functionGO:0001851 complement component C3b binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031871 proteinase activated receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008280 PMPCB / peptidase, mitochondrial processing beta subunit / O75439* / Q9CXT8* / peptidase (mitochondrial processing) beta*  / reaction
 ENSGALG00000013853 AFG3L2 / AFG3 like matrix AAA peptidase subunit 2 / Q8JZQ2* / Q9Y4W6* / AFG3-like protein 2 *  / complex
 ENSGALG00000014567 PHB2 / prohibitin-2 / O35129* / Q99623*  / complex
 ENSGALG00000011897 SMDT1 / single-pass membrane protein with aspartate rich tail 1 / Q9DB10* / Q9H4I9*  / reaction / complex
 ENSGALG00000038604 PHB / P84173 / Prohibitin / P35232* / P67778*  / complex






 

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