ENSG00000215021


Homo sapiens

Features
Gene ID: ENSG00000215021
  
Biological name :PHB2
  
Synonyms : PHB2 / prohibitin 2 / Q99623
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 6965327
Gene end: 6970825
  
Corresponding Affymetrix probe sets: 201600_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438634
Ensembl peptide - ENSP00000439029
Ensembl peptide - ENSP00000441662
Ensembl peptide - ENSP00000441875
Ensembl peptide - ENSP00000475382
Ensembl peptide - ENSP00000382362
Ensembl peptide - ENSP00000412856
Ensembl peptide - ENSP00000438068
Ensembl peptide - ENSP00000440317
NCBI entrez gene - 11331     See in Manteia.
OMIM - 610704
RefSeq - NM_001144831
RefSeq - NM_001267700
RefSeq Peptide - NP_001138303
RefSeq Peptide - NP_001254629
swissprot - U3KPZ5
swissprot - F5GWA7
swissprot - F5GY37
swissprot - F5H0C5
swissprot - F5H2D2
swissprot - F5H3X6
swissprot - J3KPX7
swissprot - Q99623
Ensembl - ENSG00000215021
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phb2aENSDARG00000045297Danio rerio
 phb2bENSDARG00000017728Danio rerio
 PHB2ENSGALG00000014567Gallus gallus
 Phb2ENSMUSG00000004264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000163  Prohibitin
 IPR001107  Band 7 domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport TAS
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007062 sister chromatid cohesion IDA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0031536 positive regulation of exit from mitosis IMP
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0030331 estrogen receptor binding NAS
 molecular_functionGO:0033218 amide binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105819 PMPCB / O75439 / peptidase, mitochondrial processing beta subunit  / reaction
 ENSG00000197912 SPG7 / Q9UQ90 / SPG7, paraplegin matrix AAA peptidase subunit  / complex
 ENSG00000183172 SMDT1 / Q9H4I9 / single-pass membrane protein with aspartate rich tail 1  / reaction / complex
 ENSG00000162972 MAIP1 / Q8WWC4 / matrix AAA peptidase interacting protein 1  / complex
 ENSG00000215021 PHB2 / Q99623 / prohibitin 2  / complex
 ENSG00000141385 AFG3L2 / Q9Y4W6 / AFG3 like matrix AAA peptidase subunit 2  / complex
 ENSG00000167085 PHB / P35232 / prohibitin  / complex






 

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