ENSMUSG00000032135


Mus musculus

Features
Gene ID: ENSMUSG00000032135
  
Biological name :Mcam
  
Synonyms : Cell surface glycoprotein MUC18 / Mcam / Q8R2Y2
  
Possible biological names infered from orthology : melanoma cell adhesion molecule / P43121
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 44134469
Gene end: 44142727
  
Corresponding Affymetrix probe sets: 10584674 (MoGene1.0st)   1416357_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117924
Ensembl peptide - ENSMUSP00000149002
Ensembl peptide - ENSMUSP00000121090
Ensembl peptide - ENSMUSP00000034650
Ensembl peptide - ENSMUSP00000096451
NCBI entrez gene - 84004     See in Manteia.
MGI - MGI:1933966
RefSeq - XM_011242631
RefSeq - NM_023061
RefSeq - XM_006510716
RefSeq Peptide - NP_075548
swissprot - D6RFP0
swissprot - Q8R2Y2
swissprot - F7ATH5
swissprot - A0A1L1SQC5
Ensembl - ENSMUSG00000032135
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcamaENSDARG00000089643Danio rerio
 mcambENSDARG00000005368Danio rerio
 MCAMENSGALG00000030027Gallus gallus
 MCAMENSG00000076706Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcam / Q9R069 / Basal cell adhesion molecule / P50895* / basal cell adhesion molecule (Lutheran blood group)*ENSMUSG0000000298026
Alcam / Q61490 / CD166 antigen / Q13740* / activated leukocyte cell adhesion molecule*ENSMUSG0000002263619


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0003094 glomerular filtration IEA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0061042 vascular wound healing IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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