Manteia

ENSMUSG00000032532

Mus musculus

Features

Gene ID:	ENSMUSG00000032532

Biological name :	Cck

Synonyms :	Cck / Cholecystokinin Cholecystokinin-33 Cholecystokinin-12 Cholecystokinin-8 / P09240

Possible biological names infered from orthology :	cholecystokinin / P06307

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	F4
Gene start:	121489824
Gene end:	121495694

Corresponding Affymetrix probe sets:	10597817 (MoGene1.0st) 1419473_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000149410 Ensembl peptide - ENSMUSP00000150557 Ensembl peptide - ENSMUSP00000150080 Ensembl peptide - ENSMUSP00000149679 Ensembl peptide - ENSMUSP00000035120 Ensembl peptide - ENSMUSP00000149163 NCBI entrez gene - 12424 See in Manteia. MGI - MGI:88297 RefSeq - XM_017313116 RefSeq - NM_001284508 RefSeq - NM_031161 RefSeq Peptide - NP_112438 RefSeq Peptide - NP_001271437 swissprot - A0A1L1SRD3 swissprot - Q8R041 swissprot - P09240 swissprot - A0A1L1SQR9 swissprot - A0A1L1SU12 Ensembl - ENSMUSG00000032532

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ccka	ENSDARG00000070810	Danio rerio
CCK	ENSGALG00000029788	Gallus gallus
CCK	ENSG00000187094	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001651	Gastrin/cholecystokinin peptide hormone
IPR013152	Gastrin/cholecystokinin, conserved site
IPR015499	Cholecystokinin-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001662	behavioral fear response	IEA
biological_process	GO:0001764	neuron migration	IDA
biological_process	GO:0001836	release of cytochrome c from mitochondria	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007409	axonogenesis	IDA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0014049	positive regulation of glutamate secretion	IEA
biological_process	GO:0032099	negative regulation of appetite	IEA
biological_process	GO:0032461	positive regulation of protein oligomerization	IEA
biological_process	GO:0042755	eating behavior	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0051901	positive regulation of mitochondrial depolarization	IEA
biological_process	GO:0051930	regulation of sensory perception of pain	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030424	axon	IDA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043194	axon initial segment	IEA
cellular_component	GO:0043195	terminal bouton	IEA
cellular_component	GO:0043203	axon hillock	IEA
cellular_component	GO:0043204	perikaryon	IEA
molecular_function	GO:0005179	hormone activity	IEA
molecular_function	GO:0005184	neuropeptide hormone activity	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Peptide ligand-binding receptors

G alpha (q) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H
MP:0002693	abnormal pancreas physiology	"abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005319	abnormal enzyme/ coenzyme level	"altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ccl11^tm1Mer/Ccl11^tm1Mer,Ccl24^tm1Mer/Ccl24^tm1Mer Genetic Background: 129S.129S6(Cg)-Ccl24^tm1Mer Ccl11^tm1Mer

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000030898	Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*	/ complex / reaction
ENSMUSG00000029193	Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr