ENSMUSG00000029193


Mus musculus

Features
Gene ID: ENSMUSG00000029193
  
Biological name :Cckar
  
Synonyms : Cckar / Cholecystokinin receptor type A / O08786
  
Possible biological names infered from orthology : cholecystokinin A receptor / P32238
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C1
Gene start: 53697776
Gene end: 53707705
  
Corresponding Affymetrix probe sets: 10530089 (MoGene1.0st)   1421195_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031093
Ensembl peptide - ENSMUSP00000144103
NCBI entrez gene - 12425     See in Manteia.
MGI - MGI:99478
RefSeq - XM_006503707
RefSeq - NM_009827
RefSeq Peptide - NP_033957
RefSeq Peptide - NP_001334283
swissprot - O08786
swissprot - Q3TPL0
Ensembl - ENSMUSG00000029193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCKARENSDARG00000052089Danio rerio
 CCKARENSGALG00000030801Gallus gallus
 CCKARENSG00000163394Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089850
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552826
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009025
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840023
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236023
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877822
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079322
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991722
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455321
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475520
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000314  Gastrin receptor
 IPR000596  Cholecystokinin receptor type A
 IPR009126  Cholecystokinin receptor
 IPR015276  Cholecystokinin A receptor, N-terminal
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR036472  Cholecystokinin A receptor, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007586 digestion IBA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0038188 cholecystokinin signaling pathway IEA
 biological_processGO:0046883 regulation of hormone secretion IBA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004951 cholecystokinin receptor activity IBA
 molecular_functionGO:0015054 gastrin receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Foxp2tm1Momo/Foxp2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: B6.129S4-Cckartm1Kym Cckbrtm1Tom

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002646 increased cholesterol absorption "augmented ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: B6.129S4-Cckartm1Kym Cckbrtm1Tom

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0006002 abnormal small intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the small intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp2tm1Momo/Foxp2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0009854 delayed gastric emptying "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032532 Cck / P09240 / Cholecystokinin Cholecystokinin-33 Cholecystokinin-12 Cholecystokinin-8 / P06307* / cholecystokinin*  / complex / reaction






 

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