ENSMUSG00000028778


Mus musculus

Features
Gene ID: ENSMUSG00000028778
  
Biological name :Hcrtr1
  
Synonyms : Hcrtr1 / Orexin receptor type 1 / P58307
  
Possible biological names infered from orthology : hypocretin receptor 1 / O43613
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 130130217
Gene end: 130139359
  
Corresponding Affymetrix probe sets: 10516723 (MoGene1.0st)   1436295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030562
Ensembl peptide - ENSMUSP00000112630
Ensembl peptide - ENSMUSP00000113198
Ensembl peptide - ENSMUSP00000127290
NCBI entrez gene - 230777     See in Manteia.
MGI - MGI:2385650
RefSeq - XM_017320157
RefSeq - NM_001163027
RefSeq - NM_001305392
RefSeq - NM_198959
RefSeq - XM_006503061
RefSeq - XM_017320156
RefSeq Peptide - NP_001156499
RefSeq Peptide - NP_001292321
RefSeq Peptide - NP_945197
swissprot - P58307
Ensembl - ENSMUSG00000028778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HCRTR1ENSG00000121764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236069
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009031
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552828
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089825
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919323
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577323
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455322
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840022
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991720
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079320
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000204  Orexin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004059  Orexin receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway ISO
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IBA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016499 orexin receptor activity ISO
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002556 cocaine consumption 
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Oca2p-18J/Oca2p-18J
Genetic Background: B10.Cg-H2r H2-T18b Oca2p-18J/GrsrJ

 MP:0012341 low preference for an addictive substance "reduced behavioral response induced by a foreign compound, such as low consumption preference, low induced hyperactivity or stereotypic behavior" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045471 Hcrt / O55241 / Orexin Orexin-A Orexin-B / O43612* / hypocretin neuropeptide precursor*  / reaction / complex






 

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