Manteia

ENSMUSG00000024553

Mus musculus

Features

Gene ID:	ENSMUSG00000024553

Biological name :	Galr1

Synonyms :	Galanin receptor type 1 / Galr1 / P56479

Possible biological names infered from orthology :	galanin receptor 1 / P47211

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E3
Gene start:	82392496
Gene end:	82406777

Corresponding Affymetrix probe sets:	10460010 (MoGene1.0st) 1427704_a_at (Mouse Genome 430 2.0 Array) 1441329_at (Mouse Genome 430 2.0 Array) 1450568_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000066381 NCBI entrez gene - 14427 See in Manteia. MGI - MGI:1096364 RefSeq - NM_008082 RefSeq Peptide - NP_032108 swissprot - P56479 Ensembl - ENSMUSG00000024553

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*	ENSMUSG00000020793	37
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*	ENSMUSG00000035773	33
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*	ENSMUSG00000114755	32
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*	ENSMUSG00000020090	29
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*	ENSMUSG00000029917	28
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*	ENSMUSG00000058400	28
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*	ENSMUSG00000035528	28
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*	ENSMUSG00000029193	26
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*	ENSMUSG00000028778	26
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*	ENSMUSG00000032360	25
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*	ENSMUSG00000030898	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000405	Galanin receptor family
IPR003906	Galanin receptor 1
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007194	negative regulation of adenylate cyclase activity	IEA
biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0051464	positive regulation of cortisol secretion	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004966	galanin receptor activity	ISS
molecular_function	GO:0017046	peptide hormone binding	IEA
molecular_function	GO:0042923	neuropeptide binding	IEA

Pathways (from Reactome)

Pathway description

Peptide ligand-binding receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002912	abnormal excitatory postsynaptic potential	"defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Lyn^M2Btlr/Lyn⁺ Genetic Background: C57BL/6J-Lyn^M2Btlr
MP:0009712	impaired conditioned place preference behavior	"decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lyn^M2Btlr/Lyn⁺ Genetic Background: C57BL/6J-Lyn^M2Btlr

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024907	Gal / P47212 / Galanin peptides Galanin Galanin message-associated peptide / P22466* / galanin and GMAP prepropeptide*	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr