ENSMUSG00000020793


Mus musculus

Features
Gene ID: ENSMUSG00000020793
  
Biological name :Galr2
  
Synonyms : Galanin receptor type 2 / Galr2 / O88854
  
Possible biological names infered from orthology : galanin receptor 2 / O43603
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 116280939
Gene end: 116283938
  
Corresponding Affymetrix probe sets: 10382788 (MoGene1.0st)   1422942_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054062
NCBI entrez gene - 14428     See in Manteia.
MGI - MGI:1337018
RefSeq - XM_011248729
RefSeq - NM_010254
RefSeq - XM_011248727
RefSeq - XM_011248728
RefSeq Peptide - NP_034384
swissprot - O88854
Ensembl - ENSMUSG00000020793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 galr2aENSDARG00000020853Danio rerio
 GALR2ENSGALG00000002088Gallus gallus
 GALR2ENSG00000182687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475551
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455335
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577331
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919326
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009026
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089825
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552824
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877823
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236022
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840021
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000405  Galanin receptor family
 IPR003907  Galanin receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0043647 inositol phosphate metabolic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0090663 galanin-activated signaling pathway IEA
 biological_processGO:1902608 positive regulation of large conductance calcium-activated potassium channel activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004966 galanin receptor activity IBA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001022 abnormal L5 ganglion morphology "malformation or absence of the L5 ganglion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024907 Gal / P47212 / Galanin peptides Galanin Galanin message-associated peptide / P22466* / galanin and GMAP prepropeptide*  / complex / reaction






 

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