ENSMUSG00000058400


Mus musculus

Features
Gene ID: ENSMUSG00000058400
  
Biological name :Qrfpr
  
Synonyms : P83861 / pyroglutamylated RFamide peptide receptor / Qrfpr
  
Possible biological names infered from orthology : Q96P65
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 36179424
Gene end: 36222313
  
Corresponding Affymetrix probe sets: 10497808 (MoGene1.0st)   1457048_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143773
Ensembl peptide - ENSMUSP00000088768
NCBI entrez gene - 229214     See in Manteia.
MGI - MGI:2677633
RefSeq - NM_198192
RefSeq Peptide - NP_937835
swissprot - A0A0G2JH05
swissprot - P83861
swissprot - Q4VA00
Ensembl - ENSMUSG00000058400
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 QRFPRENSDARG00000101969Danio rerio
 qrfpraENSDARG00000039349Danio rerio
 QRFPRENSGALG00000037740Gallus gallus
 QRFPRENSG00000186867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991773
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552825
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009024
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236023
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919323
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089822
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455322
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877821
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577319
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475519
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000611  Neuropeptide Y receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0004983 neuropeptide Y receptor activity IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0006392 abnormal nucleus pulposus morphology "any anomaly in the structure or formation of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000043102 Qrfp / Q8CE23 / Orexigenic neuropeptide QRFP QRF-amide / P83859* / pyroglutamylated RFamide peptide*  / reaction / complex






 

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