ENSMUSG00000030898


Mus musculus

Features
Gene ID: ENSMUSG00000030898
  
Biological name :Cckbr
  
Synonyms : Cckbr / Gastrin/cholecystokinin type B receptor / P56481
  
Possible biological names infered from orthology : cholecystokinin B receptor / P32239
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 105425731
Gene end: 105470898
  
Corresponding Affymetrix probe sets: 10555935 (MoGene1.0st)   1454770_at (Mouse Genome 430 2.0 Array)   1460663_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033189
Ensembl peptide - ENSMUSP00000138052
NCBI entrez gene - 12426     See in Manteia.
MGI - MGI:99479
RefSeq - XM_006507281
RefSeq - NM_007627
RefSeq - XM_006507280
RefSeq Peptide - NP_031653
swissprot - Q3ZB46
swissprot - Q8BYG7
swissprot - P56481
Ensembl - ENSMUSG00000030898
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCKBRENSDARG00000076824Danio rerio
 si:dkey-1h24.2ENSDARG00000074117Danio rerio
 CCKBRENSGALG00000039837Gallus gallus
 CCKBRENSG00000110148Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919348
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877823
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236023
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009022
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840021
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079320
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991719
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552819
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455318
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577318
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000314  Gastrin receptor
 IPR009126  Cholecystokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0038188 cholecystokinin signaling pathway IEA
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048732 gland development IMP
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004951 cholecystokinin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015054 gastrin receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031741 type B gastrin/cholecystokinin receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: B6.129S4-Cckartm1Kym Cckbrtm1Tom

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorasg/Rora+
Genetic Background: involves: C57BL/6J

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0004152 abnormal circulating iron level "anomalous blood concentration of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004731 increased circulating gastrin level "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: B6.129S4-Cckartm1Kym Cckbrtm1Tom

 MP:0005218 abnormal pancreatic delta cell morphology "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1atm1Dpk/Ppargc1atm1Dpk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cckbrtm1Tom/Cckbr+
Genetic Background: B6.129S4-Cckbrtm1Tom

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009753 enhanced behavioral response to morphine "increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009854 delayed gastric emptying "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010803 abnormal stomach enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpltm1Bres/Lpl+
Genetic Background: involves: 129S4/SvJae

 MP:0011891 decreased circulating ferritin level "reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011897 decreased circulating unsaturated transferrin level "reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017165 Gast / P48757 / Gastrin Gastrin-71 Big gastrin Gastrin / P01350* / gastrin*  / complex / reaction
 ENSMUSG00000032532 Cck / P09240 / Cholecystokinin Cholecystokinin-33 Cholecystokinin-12 Cholecystokinin-8 / P06307* / cholecystokinin*  / complex / reaction






 

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