ENSG00000110148


Homo sapiens

Features
Gene ID: ENSG00000110148
  
Biological name :CCKBR
  
Synonyms : CCKBR / cholecystokinin B receptor / P32239
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 6259736
Gene end: 6272127
  
Corresponding Affymetrix probe sets: 210381_s_at (Human Genome U133 Plus 2.0 Array)   234475_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432079
Ensembl peptide - ENSP00000437001
Ensembl peptide - ENSP00000435675
Ensembl peptide - ENSP00000435534
Ensembl peptide - ENSP00000335544
NCBI entrez gene - 887     See in Manteia.
OMIM - 118445
RefSeq - NM_176875
RefSeq - XM_017018516
RefSeq - XM_005253210
RefSeq - NM_001318029
RefSeq Peptide - NP_001304958
RefSeq Peptide - NP_795344
swissprot - E9PJ49
swissprot - P32239
swissprot - E9PIC8
swissprot - E9PPL7
Ensembl - ENSG00000110148
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCKBRENSDARG00000076824Danio rerio
 si:dkey-1h24.2ENSDARG00000074117Danio rerio
 CCKBRENSGALG00000039837Gallus gallus
 CckbrENSMUSG00000030898Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCKAR / P32238 / cholecystokinin A receptorENSG0000016339448
HCRTR2 / O43614 / hypocretin receptor 2ENSG0000013725223
HCRTR1 / O43613 / hypocretin receptor 1ENSG0000012176423
GALR2 / O43603 / galanin receptor 2ENSG0000018268722
NPFFR1 / Q9GZQ6 / neuropeptide FF receptor 1ENSG0000014873422
NPFFR2 / Q9Y5X5 / neuropeptide FF receptor 2ENSG0000005629121
GALR3 / O60755 / galanin receptor 3ENSG0000012831019
QRFPR / Q96P65 / pyroglutamylated RFamide peptide receptorENSG0000018686719
KISS1R / Q969F8 / KISS1 receptorENSG0000011601419
GALR1 / P47211 / galanin receptor 1ENSG0000016657318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000314  Gastrin receptor
 IPR009126  Cholecystokinin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway NAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0038188 cholecystokinin signaling pathway IDA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048732 gland development IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004951 cholecystokinin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015054 gastrin receptor activity IDA
 molecular_functionGO:0017046 peptide hormone binding IPI
 molecular_functionGO:0031741 type B gastrin/cholecystokinin receptor binding IDA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184502 GAST / P01350 / gastrin  / reaction / complex
 ENSG00000187094 CCK / P06307 / cholecystokinin  / reaction / complex






 

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