ENSG00000137252


Homo sapiens

Features
Gene ID: ENSG00000137252
  
Biological name :HCRTR2
  
Synonyms : HCRTR2 / hypocretin receptor 2 / O43614
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p12.1
Gene start: 55106460
Gene end: 55282620
  
Corresponding Affymetrix probe sets: 207393_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359899
Ensembl peptide - ENSP00000477548
NCBI entrez gene - 3062     See in Manteia.
OMIM - 602393
RefSeq - XM_017010798
RefSeq - NM_001526
RefSeq Peptide - NP_001517
swissprot - O43614
swissprot - S4X0W3
Ensembl - ENSG00000137252
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcrtr2ENSDARG00000023722Danio rerio
 HCRTR2ENSGALG00000016297Gallus gallus
 Hcrtr2ENSMUSG00000032360Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCRTR1 / O43613 / hypocretin receptor 1ENSG0000012176465
NPFFR1 / Q9GZQ6 / neuropeptide FF receptor 1ENSG0000014873430
NPFFR2 / Q9Y5X5 / neuropeptide FF receptor 2ENSG0000005629128
CCKBR / P32239 / cholecystokinin B receptorENSG0000011014824
CCKAR / P32238 / cholecystokinin A receptorENSG0000016339423
QRFPR / Q96P65 / pyroglutamylated RFamide peptide receptorENSG0000018686723
GALR1 / P47211 / galanin receptor 1ENSG0000016657320
KISS1R / Q969F8 / KISS1 receptorENSG0000011601420
GALR2 / O43603 / galanin receptor 2ENSG0000018268720
GALR3 / O60755 / galanin receptor 3ENSG0000012831017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000204  Orexin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004060  Orexin receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0010840 regulation of circadian sleep/wake cycle, wakefulness ISS
 biological_processGO:0022410 circadian sleep/wake cycle process IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IBA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008188 neuropeptide receptor activity TAS
 molecular_functionGO:0016499 orexin receptor activity IDA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161610 HCRT / O43612 / hypocretin neuropeptide precursor  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr