ENSG00000056291


Homo sapiens

Features
Gene ID: ENSG00000056291
  
Biological name :NPFFR2
  
Synonyms : neuropeptide FF receptor 2 / NPFFR2 / Q9Y5X5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 72031804
Gene end: 72148067
  
Corresponding Affymetrix probe sets: 224169_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379321
Ensembl peptide - ENSP00000307822
Ensembl peptide - ENSP00000340789
Ensembl peptide - ENSP00000351599
NCBI entrez gene - 10886     See in Manteia.
OMIM - 607449
RefSeq - XM_011531554
RefSeq - NM_001144756
RefSeq - NM_004885
RefSeq - NM_053036
RefSeq Peptide - NP_001138228
RefSeq Peptide - NP_004876
RefSeq Peptide - NP_444264
swissprot - Q9Y5X5
swissprot - A0PJM9
Ensembl - ENSG00000056291
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPFFR2ENSDARG00000033635Danio rerio
 npffr2bENSDARG00000060702Danio rerio
 NPFFR2ENSGALG00000011616Gallus gallus
 Npffr2ENSMUSG00000035528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPFFR1 / Q9GZQ6 / neuropeptide FF receptor 1ENSG0000014873440
HCRTR2 / O43614 / hypocretin receptor 2ENSG0000013725224
HCRTR1 / O43613 / hypocretin receptor 1ENSG0000012176423
QRFPR / Q96P65 / pyroglutamylated RFamide peptide receptorENSG0000018686723
CCKAR / P32238 / cholecystokinin A receptorENSG0000016339421
GALR1 / P47211 / galanin receptor 1ENSG0000016657319
GALR2 / O43603 / galanin receptor 2ENSG0000018268718
CCKBR / P32239 / cholecystokinin B receptorENSG0000011014818
KISS1R / Q969F8 / KISS1 receptorENSG0000011601416
GALR3 / O60755 / galanin receptor 3ENSG0000012831015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005395  Neuropeptide FF receptor family
 IPR005397  Neuropeptide FF receptor, type 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0009582 detection of abiotic stimulus TAS
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0045761 regulation of adenylate cyclase activity IEA
 biological_processGO:1901652 response to peptide IBA
 biological_processGO:2000479 regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0008188 neuropeptide receptor activity IEA
 molecular_functionGO:0031628 opioid receptor binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139574 NPFF / O15130 / neuropeptide FF-amide peptide precursor  / complex / reaction






 

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