ENSMUSG00000020090


Mus musculus

Features
Gene ID: ENSMUSG00000020090
  
Biological name :Npffr1
  
Synonyms : neuropeptide FF receptor 1 / Npffr1
  
Possible biological names infered from orthology : Q9GZQ6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 61595492
Gene end: 61628565
  
Corresponding Affymetrix probe sets: 10363492 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000020287
NCBI entrez gene - 237362     See in Manteia.
MGI - MGI:2685082
RefSeq - NM_001177511
RefSeq Peptide - NP_001170982
swissprot - E9Q468
Ensembl - ENSMUSG00000020090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npffr1ENSDARG00000111997Danio rerio
 NPFFR1ENSGALG00000004446Gallus gallus
 NPFFR1ENSG00000148734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552846
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877830
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236030
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840025
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991725
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919325
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089823
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455323
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079322
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475521
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005395  Neuropeptide FF receptor family
 IPR005396  Neuropeptide FF receptor, type 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0008188 neuropeptide receptor activity IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0005133 increased luteinizing hormone level "higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023052 Npff / Q9WVA8 / Pro-FMRFamide-related neuropeptide FF Neuropeptide SF Neuropeptide FF Neuropeptide AF-like / O15130* / neuropeptide FF-amide peptide precursor*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr