ENSMUSG00000032786


Mus musculus

Features
Gene ID: ENSMUSG00000032786
  
Biological name :Alas1
  
Synonyms : 5-aminolevulinate synthase, nonspecific, mitochondrial / Alas1 / Q8VC19
  
Possible biological names infered from orthology : 5-aminolevulinate synthase 1 / P13196
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 106233455
Gene end: 106248654
  
Corresponding Affymetrix probe sets: 10596454 (MoGene1.0st)   1424126_at (Mouse Genome 430 2.0 Array)   1442331_at (Mouse Genome 430 2.0 Array)   1455282_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117014
Ensembl peptide - ENSMUSP00000151891
Ensembl peptide - ENSMUSP00000150950
Ensembl peptide - ENSMUSP00000150311
Ensembl peptide - ENSMUSP00000122117
Ensembl peptide - ENSMUSP00000119968
Ensembl peptide - ENSMUSP00000073725
Ensembl peptide - ENSMUSP00000108143
NCBI entrez gene - 11655     See in Manteia.
MGI - MGI:87989
RefSeq - NM_020559
RefSeq - NM_001291835
RefSeq Peptide - NP_001278764
RefSeq Peptide - NP_065584
swissprot - F6RYA6
swissprot - Q3V0B2
swissprot - D6RGR8
swissprot - Q8VC19
swissprot - A0A1W2P873
swissprot - A0A1L1SUZ0
swissprot - A0A1L1STE9
swissprot - A0A0R4J0X2
Ensembl - ENSMUSG00000032786
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alas1ENSDARG00000021059Danio rerio
 ALAS1ENSGALG00000003948Gallus gallus
 ALAS1ENSG00000023330Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alas2 / P08680 / 5-aminolevulinate synthase, erythroid-specific, mitochondrial / P22557* / 5-aminolevulinate synthase 2*ENSMUSG0000002527057
Gcat / O88986 / 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial / O75600* / glycine C-acetyltransferase*ENSMUSG0000000637820
Gcat / O75600* / glycine C-acetyltransferase*ENSMUSG0000011637818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001917  Aminotransferase, class-II, pyridoxal-phosphate binding site
 IPR004839  Aminotransferase, class I/classII
 IPR010961  Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
 IPR015118  5-aminolevulinate synthase presequence
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0033014 tetrapyrrole biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003870 5-aminolevulinate synthase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032786 Alas1 / Q8VC19 / 5-aminolevulinate synthase, nonspecific, mitochondrial / P13196* / 5-aminolevulinate synthase 1*  / complex






 

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contact: otassy@igbmc.fr