Manteia - Molecule gene

ENSMUSG00000032864

Mus musculus

Features

Gene ID:	ENSMUSG00000032864

Biological name :	Rag2

Synonyms :	P21784 / Rag2 / recombination activating gene 2

Possible biological names infered from orthology :	P55895 / recombination activating 2

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	E2
Gene start:	101624718
Gene end:	101632529

Corresponding Affymetrix probe sets:	10474105 (MoGene1.0st) 1418065_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000038204 Ensembl peptide - ENSMUSP00000106858 NCBI entrez gene - 19374 See in Manteia. MGI - MGI:97849 RefSeq - XM_017316606 RefSeq - NM_009020 RefSeq Peptide - NP_033046 swissprot - P21784 swissprot - Q542D1 Ensembl - ENSMUSG00000032864

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rag2	ENSDARG00000052121	Danio rerio
RAG2	ENSGALG00000046408	Gallus gallus
RAG2	ENSG00000175097	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR004321	V-D-J recombination activating protein 2
IPR011011	Zinc finger, FYVE/PHD-type
IPR011043	Galactose oxidase/kelch, beta-propeller
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR015915	Kelch-type beta propeller
IPR025162	Recombination activating protein 2, PHD domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002326	B cell lineage commitment	IMP
biological_process	GO:0002331	pre-B cell allelic exclusion	IMP
biological_process	GO:0002358	B cell homeostatic proliferation	IMP
biological_process	GO:0002360	T cell lineage commitment	IMP
biological_process	GO:0006310	DNA recombination	TAS
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0030183	B cell differentiation	IMP
biological_process	GO:0030217	T cell differentiation	IMP
biological_process	GO:0033077	T cell differentiation in thymus	IMP
biological_process	GO:0033151	V(D)J recombination	IMP
biological_process	GO:0042742	defense response to bacterium	IGI
biological_process	GO:0046622	positive regulation of organ growth	IMP
cellular_component	GO:0005634	nucleus	IC
cellular_component	GO:0005654	nucleoplasm	TAS
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA
molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA
molecular_function	GO:0008270	zinc ion binding	IDA
molecular_function	GO:0035064	methylated histone binding	IDA
molecular_function	GO:0035091	phosphatidylinositol binding	IDA
molecular_function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IDA
molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Libo/Rag2^tm1Libo Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0000238	deficiency of pre-B cells	"lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ttr^tm1Wsb/Ttr^tm1Wsb Genetic Background: involves: 129S/SvEv * MF1
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Mir155^tm1Rsky/Mir155^tm1Rsky Genetic Background: involves: 129/Sv * C57BL/6
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0000462	abnormal digestive system morphology	"anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Etl4^{Gt(6LSN)6029Gos}/Etl4^{Gt(6LSN)6029Gos} Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6) Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ciita^tm1Ccum/Ciita^tm1Ccum Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mc1r^taw/Mc1r^e Genetic Background: involves: M. m. molossinus * C57BL/6J
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0000708	thymus hyperplasia	"increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Igh^tm1.2Rsky/Igh⁺,Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: involves: BALB/c * C57BL/6
MP:0000714	increased thymocyte number	"greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbata^tm1Faf/Tbata^tm1Faf Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Igh-Pim1)1Brn/0 Genetic Background: involves: 129S/SvEv * C57BL/6LiA * CBA
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Abca1^tm1Jdm/Abca1⁺ Genetic Background: DBA/1LacJ-Abca1^tm1Jdm Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0000727	absent CD4-8+ cells	"lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Akt1^tm1Pnt/Akt1^tm1Pnt,Akt2^tm1.1Mbb/Akt2^tm1.1Mbb,Akt3^tm1Mbb/Akt3^tm1Mbb,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Atraid^{Gt(OST23679)Lex}/Atraid⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atraid^{Gt(OST23679)Lex}/Atraid⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Pdpk1^tm1.1Mlw/Pdpk1^tm1.1Mlw,Rag2^tm1Fwa/Rag2^tm1Fwa,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Pdpk1^tm1.1Mlw/Pdpk1^tm1.1Mlw,Rag2^tm1Fwa/Rag2^tm1Fwa,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lama2^tm1Stk/Lama2^tm1Stk Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Taar1^m1J/Taar1⁺ Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001273	decreased metastatic potential		Show Allelic Composition: Mmp9^tm1Tvu/Mmp9^tm1Tvu,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Wnk1)Clhu}/Gt(ROSA)26Sor⁺,Kdr^tm1(cre)Sato/Kdr⁺,Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex} Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lepr^Db-2Btlr/Lepr⁺ Genetic Background: C57BL/6J-Lepr^Db-2Btlr Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac Allelic Composition: Gpr15^tm1.1Litt/Gpr15^tm1.1Litt,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraTcrb)425Cbn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Rag2^tm1.1Cgn/Rag2^tm1.1Cgn Genetic Background: C57BL/6-Rag2^tm1.1Cgn Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^m1Btlr/Rag2^m1Btlr Genetic Background: C57BL/6J-Rag2^m1Btlr
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^m1Btlr/Rag2^m1Btlr Genetic Background: C57BL/6J-Rag2^m1Btlr
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Rag2^tm1.1Cgn/Rag2^tm1.1Cgn Genetic Background: C57BL/6-Rag2^tm1.1Cgn Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: H2^d/H2^d,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: H2^b/H2^b,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/?,Themis^5AT161/Themis^5AT161 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bloc1s5^mu-Btlr/Bloc1s5^mu-Btlr Genetic Background: C57BL/6J-Bloc1s5^mu-Btlr Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001829	increased activated T cell number	"greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trim62^tm1Akil/Trim62⁺ Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001844	autoimmune response	"condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atraid^{Gt(OST23679)Lex}/Atraid⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae Allelic Composition: Il12b^tm1Jm/Il12b^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Il12a^tm1Jm/Il12a^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S6/SvEvTac
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Apoc2^em2Arem/Apoc2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0002023	B cell derived lymphoma	"heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rag2^tm1.1Desi/Rag2^tm1.1Desi Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J Allelic Composition: Rag2^tm1Fwa/Rag2⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(LPV-TAg1135)11Tvd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Rag2^tm1Fwa/Rag2⁺,Tg(LPV-TAg1135)11Tvd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Rag2^tm1.1Desi/Rag2^tm1.1Desi,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Rag2^tm2.1Desi/Rag2^tm2.1Desi,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0002052	decreased tumor incidence	"less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp9^tm1Tvu/Mmp9^tm1Tvu,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: B6.129S-Rag2^tm1Fwa Mmp9^tm1Tvu
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Hoxa9^tm1Mrc/Hoxa9^tm1Mrc Genetic Background: B6.129S7-Hoxa9^tm1Mrc
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pde6b^rd1-2J/Pde6b^rd1-2J Genetic Background: C57BL/6J-Pde6b^rd1-2J/J Allelic Composition: Rag2^tm1Fwa/Rag2⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(LPV-TAg1135)11Tvd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Rag2^tm1Fwa/Rag2⁺,Tg(LPV-TAg1135)11Tvd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Pdpk1^tm1.1Mlw/Pdpk1^tm1.1Mlw,Rag2^tm1Fwa/Rag2^tm1Fwa,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mchr1^tm1Blak/Mchr1^tm1Blak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Igh^tm1.1Fwa/Igh^tm1.1Fwa,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac Allelic Composition: Rag2^tm1Libo/Rag2^tm1Libo Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nhlh1^tm1Irk/Nhlh1^tm1Irk,Nhlh2^tm1Irk/Nhlh2⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Gata3^tm1Jfz/Gata3^tm1Jfz,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-cre)1Cwi/0,Tg(Tcra5CC7,Tcrb5CC7)IWep/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbata^tm1Faf/Tbata^tm1Faf Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Sos1^tm1.1Les/Sos1^tm1.1Les,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Rag2^tm2Fwa/Rag2^tm2Fwa Genetic Background: involves: 129S6/SvEvTac
MP:0002217	small lymph nodes	"lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Etl4^{Gt(6LSN)6029Gos}/Etl4^{Gt(6LSN)6029Gos} Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pdcd10^tm1Wami/Pdcd10^tm1Wami,Emx1^tm1(cre)Krj/Emx1⁺ Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002403	abnormal pre-B cell	"anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Pdcd10^tm1Wami/Pdcd10^tm1Wami,Emx1^tm1(cre)Krj/Emx1⁺ Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0002406	increased susceptibility to infection	"greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcra^Ln3Jae/Tcra⁺,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0002408	abnormal double-positive T cell	"anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-Nfatct1)1Grc/0 Genetic Background:* involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il12b^tm1Jm/Il12b^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae Allelic Composition: Il12b^tm1Jm/Il12b^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Il2rg^tm1Cgn/Il2rg^tm1Cgn,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Il2rg^tm1.1Flv/Y,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trim62^tm1Akil/Trim62⁺ Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002429	abnormal blood cell morphology/development	"anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0002432	abnormal CD4+ T cell morphology/development	"anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bloc1s5^mu-Btlr/Bloc1s5^mu-Btlr Genetic Background: C57BL/6J-Bloc1s5^mu-Btlr Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Espl1^tm1.2Tno/Espl1^tm1.2Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Lat^tm6(DTR)Mal/?,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mir155^tm1Rsky/Mir155^tm1Rsky Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0002465	abnormal eosinophil physiology	"abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn Genetic Background: involves: C57BL/6NCrl
MP:0002656	abnormal keratinocyte differentiation	"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pdpk1^tm1.1Mlw/Pdpk1^tm1.1Mlw,Rag2^tm1Fwa/Rag2^tm1Fwa,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0002831	absent Peyer s patches	"lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Espl1^tm1.2Tno/Espl1^tm1.2Tno Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003080	competent NK cell cytolysis	"ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Lepr^Db-2Btlr/Lepr⁺ Genetic Background: C57BL/6J-Lepr^Db-2Btlr Allelic Composition: Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac
MP:0003293	rectal hemorrhage	"bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0003304	large intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0003331	hepatocellular carcinoma	"malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Mmp9^tm1Tvu/Mmp9^tm1Tvu,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0003448	altered tumor morphology	"changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Mmp9^tm1Tvu/Mmp9^tm1Tvu,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0003449	abnormal intestinal goblet cells	"malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0003454	erythroderma	"exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95549]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0003504	thyroid inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0,Tg(TLK2mHEL)2Ccg/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003560	osteoarthritis	"a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]	Show Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv,Casp6^tm1Flv/Casp6^tm1Flv Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0003702	abnormal chromosome morphology	"anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0003790	absent CD4+8- cells	"lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Lck-Akt1)M-1Pnt/0 Genetic Background:* involves: 129S/SvEv * C3H/He * C57BL/6
MP:0003850	abnormal thymocyte activation/response	"anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: H2^b/H2^b,Nfkbid^tm1Clay/Nfkbid^tm1Clay,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
MP:0003945	abnormal lymphocyte physiology	"abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0004001	decreased hepatocyte proliferation	"reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0004024	aneuploidy	"chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0004029	spontaneous chromosome breakage	"chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4^tm1Fwa/Xrcc4^tm2Fwa Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0004392	abnormal CD8-positive T cell physiology	"abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gucy2d^tm1Mom/Gucy2d^tm1Mom,Sema3f^tm1Mom/Sema3f^tm1Mom Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mog^tm1(cre)Gkl/Mog^tm1(cre)Gkl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0 Genetic Background: C57BL/6-Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1Cgn,Tg(Cr2-cre)3Cgn/?,Xrcc4^tm1Fwa/Xrcc4^tm2Fwa Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004904	increased uterus weight	"increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0004919	abnormal positive T cell selection	"any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]	Show Allelic Composition: Igh^tm1.2Rsky/Igh⁺,Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16⁺,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0004939	abnormal B cell morphology	"any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gucy2d^tm1Mom/Gucy2d^tm1Mom,Sema3f^tm1Mom/Sema3f^tm1Mom Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Cd8a^tm1Asin/Cd8a^tm1Asin,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/? Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn Genetic Background: involves: C57BL/6NCrl
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Cd47^tm1Fpl/Cd47^tm1Fpl,Il2rg^tm1Cgn/Y Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rag2^tm1Libo/Rag2^tm1Libo Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Rag2^m1Btlr/Rag2^m1Btlr Genetic Background: C57BL/6J-Rag2^m1Btlr
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005026	decreased susceptibility to parasitic infection	"reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005036	diarrhea	"abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0005078	abnormal cytotoxic T cell physiology	"impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gucy2d^tm1Mom/Gucy2d^tm1Mom,Sema3f^tm1Mom/Sema3f^tm1Mom Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: H2^b/H2^b,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Igh^tm1.2Rsky/Igh⁺,Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Lck-Akt1)M-1Pnt/0 Genetic Background:* involves: 129S/SvEv * C3H/He * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/?,Themis^5AT161/Themis^5AT161 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0,Tg(TLK2mHEL)2Ccg/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Ctcf^tm1Laat/Ctcf^tm1Laat,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * C57BL/10 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Rag2^tm1.1Cgn/Rag2^tm1.1Cgn,Tg(Lck-cre)548Jxm/0,Tg(TcrAND)53Hed/0 Genetic Background: B6.Cg-Rag2^tm1.1Cgn Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm Tg(TcrAND)53Hed
MP:0005094	abnormal T cell proliferation	"anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bloc1s5^mu-Btlr/Bloc1s5^mu-Btlr Genetic Background: C57BL/6J-Bloc1s5^mu-Btlr Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: H2^b/H2^b,Nfkbid^tm1Clay/Nfkbid^tm1Clay,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Sos1^tm1.1Les/Sos1^tm1.1Les,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: H2^b/H2^b,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Ccnd3^tm1Pisc/Ccnd3^tm1Pisc,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005463	abnormal CD4+ T cell physiology	"anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0,Tg(TLK2mHEL)2Ccg/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005465	abnormal T helper 1 physiology	"anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005517	decreased liver regeneration	"less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kras^tm4Tyj/Kras⁺,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Cdh5^tm1Hub/Cdh5^tm1Hub Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	"less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005671	response to transplant	"the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Il2rg^tm1.1Flv/Y,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac Allelic Composition: Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Rag2^tm1.1Flv/Rag2^tm1.1Flv,Tg(SIRPA)1Flv/0,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Tg(SIRPA)1Flv/0,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac
MP:0005673	decreased susceptibility to graft versus host disease	"less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Cd47^tm1Fpl/Cd47^tm1Fpl,Il2rg^tm1Cgn/Y Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Atraid^{Gt(OST23679)Lex}/Atraid⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0006387	abnormal T cell number	"deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0008037	abnormal T cell morphology	"any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Il2rg^tm1Cgn/Y,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: B6.129-Rag2^tm1Fwa Il2rg^tm1Cgn Allelic Composition: Il15^tm1Imx/Il15^tm1Imx,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Il2rb^tm1Mak/Il2rb^tm1Mak,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129 * 129S/SvEv Allelic Composition: Il2rg^tm1Cgn/Il2rg^tm1Cgn,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0008046	absent NK cells	"absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Il2rg^tm1Cgn/Y,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: B6.129-Rag2^tm1Fwa Il2rg^tm1Cgn Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae
MP:0008070	absent T cells	"absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il2rg^tm1Cgn/Y,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: B6.129-Rag2^tm1Fwa Il2rg^tm1Cgn Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae
MP:0008071	absent B cells	"absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il2rg^tm1Cgn/Y,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: B6.129-Rag2^tm1Fwa Il2rg^tm1Cgn
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rspo2^tm1Nuv/Rspo2⁺ Genetic Background: involves: 129 * C57BL/6
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2 Allelic Composition: H2^d/H2^d,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: H2^b/H2^b,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0,Tg(TLK2mHEL)2Ccg/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcra^Ln3Jae/Tcra⁺,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16⁺,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Rag2^m1Btlr/Rag2^m1Btlr Genetic Background: C57BL/6J-Rag2^m1Btlr Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Cd47^tm1Fpl/Cd47^tm1Fpl,Il2rg^tm1Cgn/Y Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0008076	abnormal CD4-positive T cell differentiation	"atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2 Allelic Composition: Lime1^tm1Mal/Lime1^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: B6.Cg-Rag2^tm1Fwa Lime1^tm1Mal Tg(TcraH-Y,TcrbH-Y)1Pas
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: H2^b/H2^b,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcra^Ln3Jae/Tcra⁺,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Cd47^tm1Fpl/Cd47^tm1Fpl,Il2rg^tm1Cgn/Y Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: H2^d/H2^d,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16⁺,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis^5AT161/Themis^5AT161 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16^tm1Mal,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Prss16^tm1Mal/Prss16⁺,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/? Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0008174	decreased follicular B cell number	"reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Libo/Rag2^tm1Libo Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss Genetic Background: involves: 129S6/SvEvTac
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008212	absent mature B cells	"absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008213	absent immature B cells	"absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Cgn/Rag2^tm1.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008348	absent gamma-delta T cells	"absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcra^Ln3Jae/Tcra⁺,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tcrb^Ln3Jae/Tcrb⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0008356	abnormal gamma-delta T cell differentiation	"atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Rag2^tm1Mao/Rag2^tm1Mao Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Mao Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008464	absent peripheral lymph nodes	"absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Cd47^tm1Fpl/Cd47^tm1Fpl,Il2rg^tm1Cgn/Y Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0008466	enlarged mesenteric lymph nodes	"increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor,Rag2^tm1Fwa/Rag2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0008555	abnormal interferon secretion	"anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae Allelic Composition: Il12b^tm1Jm/Il12b^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Il12a^tm1Jm/Il12a^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S6/SvEvTac
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0008568	abnormal interleukin secretion	"anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Il2rg^tm1Cgn/Il2rg^tm1Cgn,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0008588	abnormal circulating interleukin level	"anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008682	decreased interleukin-17 secretion	"reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008688	decreased interleukin-2 secretion	"reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: H2^b/H2^b,Nfkbid^tm1Clay/Nfkbid^tm1Clay,Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcraN15,TcrbN15)L2Elre/? Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
MP:0008722	abnormal chemokine secretion	"anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Il12b^tm1Jm/Il12b^tm1Jm,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0008754	abnormal T cell receptor V(D)J recombination	"any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008755	abnormal immunoglobulin V(D)J recombination	"any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Six5^tm1Rdd/Six5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Rag2^tm1.1Desi/Rag2^tm1.1Desi Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008759	abnormal T cell receptor delta chain V(D)J recombination	"any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednra^tm2Ywa/Ednra^tm2Ywa,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: C57BL/6J * CBA/J
MP:0008827	abnormal thymus cell ratio	"deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(TcrHEL3A9)1Mmd/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009278	abnormal bone marrow cell physiology	"any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbata^tm1Faf/Tbata^tm1Faf Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0009515	gastrointestinal stromal tumor	"non-epithelial, mesenchymal tumors of the gastrointestinal tract, thought to originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract; approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum; GISTs are tumors of connective tissue, i.e. sarcomas, account for 1-3% of all gastrointestinal malignancies in human, and are typically more cellular than other gastrointestinal sarcomas" [http://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", OMIM:606764]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0009540	absent Hassall s corpuscle	"absence of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0009624	small inguinal lymph nodes	"reduced size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * 129S4/SvJae
MP:0009788	increased susceptibility to bacterial infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd274^tm1Lpc/Cd274^tm1Lpc Genetic Background: C.129S-Cd274^tm1Lpc
MP:0009789	decreased susceptibility to bacterial infection induced morbidity/mortality	"reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0010133	increased DN3 thymocyte number	"increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]	Show Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0010219	increased T-helper 17 cell number	"increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]	Show Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0010279	increased gastrointestinal tumor incidence	"greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Stat1^tm1Rds/Stat1^tm1Rds Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0010365	increased thymus tumor incidence	"greater than the expected number of neoplams in the thymus occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster
MP:0010792	abnormal stomach mucosa morphology	"any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Rag2^tm1.1Mss/Rag2^tm1.1Mss,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0013956	decreased colon length	"reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]	Show Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0020184	altered susceptibility to parasitic infection	"a change in the likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by a parasite" [GOC:NV]	Show Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn,Rag2^tm1.1Cgn/Rag2^tm1.1Cgn Genetic Background: involves: C57BL/6NCrl
MP:0030011	small cervical lymph nodes	"reduced size of the lymph nodes found near the neck and shoulders" [MGI:anna]	Show Allelic Composition: Rag2^tm1Avla/Rag2^tm1Avla Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000061311	Rag1 / P15919 / V(D)J recombination-activating protein 1 Endonuclease RAG1 E3 ubiquitin-protein ligase RAG1 / P15918* / recombination activating 1*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr