ENSMUSG00000061311


Mus musculus

Features
Gene ID: ENSMUSG00000061311
  
Biological name :Rag1
  
Synonyms : P15919 / Rag1 / V(D)J recombination-activating protein 1 Endonuclease RAG1 E3 ubiquitin-protein ligase RAG1
  
Possible biological names infered from orthology : P15918 / recombination activating 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 101638282
Gene end: 101649501
  
Corresponding Affymetrix probe sets: 10485372 (MoGene1.0st)   1450680_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077584
NCBI entrez gene - 19373     See in Manteia.
MGI - MGI:97848
RefSeq - NM_009019
RefSeq - XM_006499012
RefSeq Peptide - NP_033045
swissprot - P15919
Ensembl - ENSMUSG00000061311
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rag1ENSDARG00000052122Danio rerio
 RAG1ENSGALG00000007938Gallus gallus
 RAG1ENSG00000166349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR019485  V(D)J recombination-activating protein 1, Zinc finger
 IPR023336  RAG nonamer-binding domain
 IPR024627  V(D)J recombination-activating protein 1
 IPR035714  RAG1 importin-binding
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002331 pre-B cell allelic exclusion IMP
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033151 V(D)J recombination IMP
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045580 regulation of T cell differentiation IGI
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IGI
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:2000822 regulation of behavioral fear response IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IMP
 molecular_functionGO:0046872 metal ion binding IMP
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Rasa3scat/Rasa3scat
Genetic Background: involves: 129S7/SvEvBrd * BALB/cBy

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: H2g7/H2g7,Ins2tm1Jja/Ins2tm1Jja,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Lck-Akt1*)M-1Pnt/0
Genetic Background: involves: 129S/SvEv * C3H/He * C57BL/6

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pdpntm2.1Mlkn/Pdpntm2.1Mlkn,Rag1tm1Mom/Rag1tm1Mom,Tg(Pdgfrb-cre)9Rha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Plcg2Ali5/Plcg2+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1tm3.1Hcd/Fbn1tm3.1Hcd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3ap1m1Btlr/Pik3ap1m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

Allelic Composition: Rag1m2Btlr/Rag1m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grid2ho-15J/Grid2ho-15J
Genetic Background: involves: C3HeB/Fe

Allelic Composition: H2dlAb1-Ea/H2dlAb1-Ea,Rag1tm1Mom/Rag1tm1Mom,Tg(HLA-DRA,HLA-DRB5*0101)loKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(LPV-TAg1135)11Tvd/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1+,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Ewsr1tm1(ERG)Thr/Ewsr1+,Rag1tm1(cre)Thr/Rag1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cadpstm1Bros/Cadps+
Genetic Background: Not Specified

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1Fwa/Rag2+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(LPV-TAg1135)11Tvd/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1+,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax9tm1.1Hpt/Pax9tm1.1Hpt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: Rag1tm1Jsek/Rag1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: Igh-Jtm1Mcdl/Igh-Jtm1Mcdl,Igk-Jtm1Mcdl/Igk-Jtm1Mcdl,Rag1tm1Mom/Rag1tm1Mom,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rag1tm1Jsek/Rag1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

Allelic Composition: Lcktm1Mak/Lcktm1Mak,Rag1tm1Mom/Rag1+,Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mir126atm1.1Cjku/Mir126atm1.1Cjku
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm1.1Ayr/Y,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraTcrb)425Cbn/0
Genetic Background: Not Specified

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002353 abnormal inguinal lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the groin area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Igh-Jtm1Mcdl/Igh-Jtm1Mcdl,Igk-Jtm1Mcdl/Igk-Jtm1Mcdl,Rag1tm1Mom/Rag1tm1Mom,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasa3scat/Rasa3scat
Genetic Background: involves: BALB/cBy

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6btm2Dent/Bcl6btm2Dent,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tc/Tc
Genetic Background: Not Specified

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CrygbS11R/CrygbS11R,Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: A/J * C57BL/6J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igh-Jtm1Mcdl/Igh-Jtm1Mcdl,Igk-Jtm1Mcdl/Igk-Jtm1Mcdl,Rag1tm1Mom/Rag1tm1Mom,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igh-Jtm1Mcdl/Igh-Jtm1Mcdl,Igk-Jtm1Mcdl/Igk-Jtm1Mcdl,Rag1tm1Mom/Rag1tm1Mom,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/10

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Plcg2Ali5/Plcg2+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd160tm1Yxf/Cd160tm1Yxf,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.Cg-Rag1tm1Mom Cd160tm1Yxf

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: H2g7/H2g7,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: H2g7/H2q,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: H2g7/H2g7,Ins2tm1Jja/Ins2tm1Jja,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2g7/H2q,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1m2Btlr/Rag1m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pstpip2Lupo/Pstpip2Lupo,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ewsr1tm1(ERG)Thr/Ewsr1+,Rag1tm1(cre)Thr/Rag1+
Genetic Background: involves: 129S/SvEv

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Bcl6btm2Dent/Bcl6btm2Dent,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rag1m1Anu/Rag1m1Anu
Genetic Background: C57BL/6NCrlAnu-Rag1m1Anu

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: Rag1m2Btlr/Rag1m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Rag1tm1Mom/Rag1tm1Mom,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Lcktm1Mak/Lcktm1Mak,Rag1tm1Mom/Rag1+,Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rag1m2Btlr/Rag1m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm2Mal/Lattm2Mal,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: 129/Sv

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1Jsek/Rag1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0005434 deficiency of late pro-B cells "lack of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm1Rfo/Brca1tm1Rfo
Genetic Background: involves: 129P2/OlaHsd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: H2g7/H2g7,Ins2tm1Jja/Ins2tm1Jja,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Slc46a2tm1Moki/Slc46a2+,Tg(TcraB12,TcrbB12)1Rest/0
Genetic Background: involves: 129 * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Rag1coln/Rag1coln
Genetic Background: C57BL/6JAnu-Rag1coln/Apb

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Rag1coln/Rag1coln
Genetic Background: C57BL/6JAnu-Rag1coln/Apb

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Vav1tm2Tyb/Vav1tm2Tyb,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1m1Btlr/Rag1m1Btlr
Genetic Background: C57BL/6J-Rag1m1Btlr

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Rag1tm1(GFP)Imku/?,Zfp335blt/Zfp335blt
Genetic Background: involves: C57BL/6 * CBA

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1m1Btlr/Rag1m1Btlr
Genetic Background: C57BL/6J-Rag1m1Btlr

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008164 abnormal B-1a B cell morphology "any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008348 absent gamma-delta T cells "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Cd160tm1Yxf/Cd160tm1Yxf,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.Cg-Rag1tm1Mom Cd160tm1Yxf

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Rag1tm1Mom/Rag1tm1Mom,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008711 increased interleukin-9 secretion "increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(LPV-TAg1135)11Tvd/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Rag1tm1(GFP)Imku/Rag1tm1(GFP)Imku
Genetic Background: involves: C57BL/6 * CBA

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1Jsek/Rag1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rag1tm1Jsek/Rag1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Jsek/Rag1tm1Jsek,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008925 increased granule neuron number "greater number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm2Mal/Lattm2Mal,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Lattm1Mal/Lattm1Mal,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Lattm2Mal/Lattm2Mal,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Lattm1Mal/Lattm1Mal,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010250 absent thymus cortex "lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

 MP:0010932 increased trabecular bone connectivity density "increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nr3c1Gt(ESKN92)Hgs/Nr3c1+
Genetic Background: B6.Cg-Nr3c1Gt(ESKN92)Hgs

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011370 increased mesangial cell apoptosis "increase in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0013587 absent thymus medulla "lacking the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0014130 thymus cysts "presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032864 Rag2 / P21784 / recombination activating gene 2 / P55895* / recombination activating 2*  / complex






 

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