ENSMUSG00000033308


Mus musculus

Features
Gene ID: ENSMUSG00000033308
  
Biological name :Dpyd
  
Synonyms : Dihydropyrimidine dehydrogenase [NADP(+)] / Dpyd / Q8CHR6
  
Possible biological names infered from orthology : dihydropyrimidine dehydrogenase / Q12882
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 118562129
Gene end: 119432924
  
Corresponding Affymetrix probe sets: 10495625 (MoGene1.0st)   1427945_at (Mouse Genome 430 2.0 Array)   1427946_s_at (Mouse Genome 430 2.0 Array)   1443717_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143022
Ensembl peptide - ENSMUSP00000039429
NCBI entrez gene - 99586     See in Manteia.
MGI - MGI:2139667
RefSeq - NM_170778
RefSeq Peptide - NP_740748
swissprot - A0A0G2JF48
swissprot - Q8CHR6
Ensembl - ENSMUSG00000033308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpyda.1ENSDARG00000102671Danio rerio
 dpyda.3ENSDARG00000086853Danio rerio
 dpydbENSDARG00000010267Danio rerio
 DPYDENSGALG00000005509Gallus gallus
 DPYDENSG00000188641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005720  Dihydroorotate dehydrogenase domain
 IPR009051  Alpha-helical ferredoxin
 IPR013785  Aldolase-type TIM barrel
 IPR017896  4Fe-4S ferredoxin-type, iron-sulphur binding domain
 IPR017900  4Fe-4S ferredoxin, iron-sulphur binding, conserved site
 IPR023753  FAD/NAD(P)-binding domain
 IPR028261  Dihydroprymidine dehydrogenase domain II
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006145 purine nucleobase catabolic process IEA
 biological_processGO:0006208 pyrimidine nucleobase catabolic process IEA
 biological_processGO:0006210 thymine catabolic process IEA
 biological_processGO:0006212 uracil catabolic process IEA
 biological_processGO:0006214 thymidine catabolic process IEA
 biological_processGO:0019483 beta-alanine biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033308 Dpyd / Q8CHR6 / Dihydropyrimidine dehydrogenase [NADP(+)] / Q12882* / dihydropyrimidine dehydrogenase*  / complex






 

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