Manteia - Molecule gene

ENSMUSG00000034121

Mus musculus

Features

Gene ID:	ENSMUSG00000034121

Biological name :	Mks1

Synonyms :	Meckel syndrome type 1 protein homolog / Mks1 / Q5SW45

Possible biological names infered from orthology :	Meckel syndrome, type 1 / Q9NXB0

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	C
Gene start:	87853215
Gene end:	87863803

Corresponding Affymetrix probe sets:	10380189 (MoGene1.0st) 1435835_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000043790 NCBI entrez gene - 380718 See in Manteia. MGI - MGI:3584243 RefSeq - XM_006533645 RefSeq - NM_001039684 RefSeq Peptide - NP_001034773 swissprot - Q284W0 swissprot - Q5SW45 Ensembl - ENSMUSG00000034121

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mks1	ENSDARG00000059657	Danio rerio
MKS1	ENSGALG00000030979	Gallus gallus
MKS1	ENSG00000011143	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR010796	B9 domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001843	neural tube closure	IMP
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0008589	regulation of smoothened signaling pathway	IMP
biological_process	GO:0010669	epithelial structure maintenance	IMP
biological_process	GO:0030030	cell projection organization	IEA
biological_process	GO:0042733	embryonic digit morphogenesis	IMP
biological_process	GO:0044458	motile cilium assembly	IMP
biological_process	GO:0048706	embryonic skeletal system development	IMP
biological_process	GO:0048754	branching morphogenesis of an epithelial tube	IMP
biological_process	GO:0060122	inner ear receptor cell stereocilium organization	IMP
biological_process	GO:0060271	cilium assembly	IEA
biological_process	GO:0060322	head development	IMP
biological_process	GO:0060828	regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:0061009	common bile duct development	IMP
biological_process	GO:1901620	regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IMP
biological_process	GO:1905515	non-motile cilium assembly	IMP
biological_process	GO:1990403	embryonic brain development	IMP
biological_process	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0005814	centriole	IDA
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0035869	ciliary transition zone	IMP
cellular_component	GO:0036038	MKS complex	IDA
cellular_component	GO:0036064	ciliary basal body	IEA
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Hedgehog off state

Anchoring of the basal body to the plasma membrane

Hedgehog on state

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000078	abnormal supraoccipital bone morphology	"malformed upper part of the occipital bone" [J:61509]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000084	abnormal fontanelle morphology	"structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000153	rib bifurcation	"forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000413	polyphalangy	"increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdc20^tm1.2Mama/Cdc20^tm1.2Mama Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
MP:0000440	domed skull		Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000448	pointed snout	"nose tapers to a small tip, sharper angle than wild type " [J:18378]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB
MP:0000579	abnormal nail morphology	"structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mcph1^{tm1a(EUCOMM)Wtsi}/Mcph1^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Mcph1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000644	dextrocardia	"cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000866	vermis hypoplasia	"reduced cell number in the vermis" [J:61509]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0000925	abnormal floor plate morphology	"malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001943	abnormal respiration	"anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0002102	abnormal ear morphology	"structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itsn1^{Gt(pT1ATGBetageo)1Ruiz}/Itsn1^{Gt(pT1ATGBetageo)1Ruiz},Itsn2^tm1Egan/Itsn2^tm1Egan Genetic Background: involves: 129S2/SvPas
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002160	abnormal reproductive system morphology	"structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB
MP:0002188	small heart	"reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0002622	abnormal cochlear hair cell morphology	"malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002766	situs inversus	"lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002828	abnormal glomerular capsule	"anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0002928	abnormal bile duct morphology	"malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0002929	abnormal bile duct development	"incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003178	left pulmonary isomerism	"bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003327	liver cysts	"abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003342	accessory spleen	"the splenic tissue is divided into equal masses; often related to situs inversus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0003582	abnormal ovary development	"abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0003670	dilated glomerular capsule	"an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003942	abnormal urinary system development		Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004017	duplex kidney	"a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004131	abnormal embryonic ciliary morphology	"any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004133	heterotaxia	"abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004252	abnormal direction of looping morphogenesis	"deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004321	short sternum	"reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004450	presphenoid bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004491	abnormal orientation of outer hair cell stereociliary bundles	"misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0004539	absent maxilla	"missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004624	abnormal thoracic cage	"any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004860	dilated kidney collecting duct	"stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005170	cleft lip	"defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005269	abnormal occipital bone morphology	"anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0005537	abnormal cerebral aqueduct	"anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0006198	enophthalmos	"sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0008534	enlarged fourth ventricle	"increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008540	abnormal cerebrum morphology	"any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008547	abnormal neocortex morphology	"any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1 Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0010772	abnormal pollex morphology	"any structural anomaly of the first or primary digit on the radial side of the hand" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0010807	abnormal stomach position or orientation	"the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0010977	fused right lung lobes	"complete or partial fusion of the right lung lobes, indicative of defective lobar septation during embryonic lung development" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0011059	abnormal ependyma motile cilium morphology	"any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011066	abnormal renal tubule epithelial cell primary cilium morphology	"any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011293	dilated nephron	"stretched or widened aperture of the luminal space of the filtering unit of the kidney" [MGI:anna]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0011344	abnormal loop of Henle ascending limb thick segment morphology	"any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0011440	increased kidney cell proliferation	"increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011727	ectopic ovary	"appearance of an ovary in a region where it is not normally found (topographical anomaly)" [MGI:csmith]	Show Allelic Composition: Mks1^krc/Mks1^krc Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CD-1
MP:0011998	decreased embryonic cilium length	"reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0012093	absent nodal flow	"absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [MGI:anna]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0012667	split sternal manubrium	"the appearance of an abnormal division of the cranial most segment of the sternum" [MGI:anna]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0013197	decreased embryonic cilium number	"reduced number of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:anna]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0020383	decreased kidney epithelial cell primary cilium length	"decreased length of the cilia on cells of the renal tubule or collecting duct" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Mks1^hlb614/Mks1^hlb614 Genetic Background: involves: C3H * C57BL/6
MP:0030309	abnormal posterior cranial fossa morphology	"any structural anomaly of the most inferior and deepest of the cranial fossae, located between the foramen magnum and tentorium cerebelli, which houses the brainstem and cerebellum; it is bounded anteriorly and medially by the dorsum sellae of the sphenoid bone; anteriorly and laterally by the superior border of the petrous part of the temporal bone; and posteriorly by the internal surface of the squamous part of the occipital bone; its floor consists of the mastoid part of the temporal bone and the squamous, condylar and basilar parts of the occipital bone" [http://teachmeanatomy.info/head/areas/cranial-fossa/posterior/, https://radiopaedia.org/articles/posterior-cranial-fossa]	Show Allelic Composition: Mks1^{tm1a(EUCOMM)Wtsi}/Mks1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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