ENSMUSG00000034216


Mus musculus

Features
Gene ID: ENSMUSG00000034216
  
Biological name :Vps18
  
Synonyms : Q8R307 / Vps18 / VPS18 CORVET/HOPS core subunit
  
Possible biological names infered from orthology : Q9P253
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119288740
Gene end: 119298453
  
Corresponding Affymetrix probe sets: 10474950 (MoGene1.0st)   1427304_at (Mouse Genome 430 2.0 Array)   1442112_at (Mouse Genome 430 2.0 Array)   1455873_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036915
NCBI entrez gene - 228545     See in Manteia.
MGI - MGI:2443626
RefSeq - NM_172269
RefSeq Peptide - NP_758473
swissprot - Q8R307
Ensembl - ENSMUSG00000034216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps18ENSDARG00000070433Danio rerio
 VPS18ENSGALG00000008496Gallus gallus
 VPS18ENSG00000104142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR007810  Pep3/Vps18/deep orange
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035542 regulation of SNARE complex assembly IBA
 biological_processGO:0046718 viral entry into host cell IMP
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030123 AP-3 adaptor complex IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030897 HOPS complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0033263 CORVET complex IDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030674 protein binding, bridging IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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