ENSDARG00000070433


Danio rerio

Features
Gene ID: ENSDARG00000070433
  
Biological name :vps18
  
Synonyms : P59015 / vacuolar protein sorting 18 homolog (S. cerevisiae) / vps18
  
Possible biological names infered from orthology : Q8R307 / Q9P253 / VPS18, CORVET/HOPS core subunit
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 28354269
Gene end: 28361574
  
Corresponding Affymetrix probe sets: Dr.8966.1.S1_at (Zebrafish Array)   NM_173245_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000094129
NCBI entrez gene - 100005887     See in Manteia.
RefSeq - NM_173245
RefSeq Peptide - NP_775352
swissprot - B7ZVV5
swissprot - P59015
ZFIN ID - ZDB-GENE-020419-33
Ensembl - ENSDARG00000070433
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VPS18ENSGALG00000008496Gallus gallus
 VPS18ENSG00000104142Homo sapiens
 Vps18ENSMUSG00000034216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR007810  Pep3/Vps18/deep orange
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0007032 endosome organization IBA
 biological_processGO:0007040 lysosome organization IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0008333 endosome to lysosome transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015721 bile acid and bile salt transport IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035542 regulation of SNARE complex assembly IBA
 biological_processGO:0043485 endosome to pigment granule transport IMP
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0048069 eye pigmentation IMP
 biological_processGO:0048757 pigment granule maturation IMP
 biological_processGO:0060036 notochord cell vacuolation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030897 HOPS complex IBA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0030674 protein binding, bridging IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000112 gut gut hypoplastic , abnormal
Show

 ZFA:0000123 liver liver increased size , abnormal
liver quality , abnormal
Show

 ZFA:0000135 notochord notochord vacuole disorganized , abnormal
notochord vacuole broken , abnormal
Show

 ZFA:0000152 retina retina pigment granule sparse , abnormal
Show

 ZFA:0000368 integument integument pigment granule sparse , abnormal
Show

 ZFA:0001094 whole organism whole organism unpigmented , abnormal
Show

 ZFA:0001115 trunk trunk has fewer parts of type melanocyte , abnormal
trunk has fewer parts of type iridophore , abnormal
trunk decreased pigmentation , abnormal
Show

 ZFA:0005163 bile canaliculus bile canaliculus obstructed , abnormal
bile canaliculus distended , abnormal
bile canaliculus microvillus decreased length , abnormal
bile canaliculus microvillus sparse , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte quality , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte increased distance hepatocyte , abnormal
hepatocyte increased size , abnormal
hepatocyte lysosome decreased amount , abnormal
hepatocyte vacuole increased amount , abnormal
Show

 ZFA:0009199 iridophore iridophore decreased amount , abnormal
iridophore quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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