ENSMUSG00000035284


Mus musculus

Features
Gene ID: ENSMUSG00000035284
  
Biological name :Vps13c
  
Synonyms : Q8BX70 / vacuolar protein sorting 13C / Vps13c
  
Possible biological names infered from orthology : Q709C8 / vacuolar protein sorting 13 homolog C
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 67840396
Gene end: 67995638
  
Corresponding Affymetrix probe sets: 10586616 (MoGene1.0st)   1448011_at (Mouse Genome 430 2.0 Array)   1456535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077040
Ensembl peptide - ENSMUSP00000150974
Ensembl peptide - ENSMUSP00000149945
Ensembl peptide - ENSMUSP00000149778
NCBI entrez gene - 320528     See in Manteia.
MGI - MGI:2444207
RefSeq - XM_006511226
RefSeq - NM_177184
RefSeq - XM_006511224
RefSeq - XM_006511225
RefSeq Peptide - NP_796158
swissprot - A1ILG8
swissprot - Q8BX70
swissprot - A0A1L1SSJ3
swissprot - A0A1L1SS63
swissprot - A0A1L1SUY8
Ensembl - ENSMUSG00000035284
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps13cENSDARG00000074465Danio rerio
 VPS13CENSGALG00000003705Gallus gallus
 Q709C8ENSG00000129003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5H8C4 / Vps13a / vacuolar protein sorting 13A / Q96RL7* / vacuolar protein sorting 13 homolog A*ENSMUSG0000004623036
Vps13d / vacuolar protein sorting 13D / Q5THJ4* / vacuolar protein sorting 13 homolog D*ENSMUSG0000002022020
Q80TY5 / Vps13b / vacuolar protein sorting 13B / Q7Z7G8* / vacuolar protein sorting 13 homolog B*ENSMUSG0000003764613


Protein motifs (from Interpro)
Interpro ID Name
 IPR009543  Vacuolar protein sorting-associated protein 13, SHR-binding domain
 IPR015412  Autophagy-related, C-terminal
 IPR026847  Vacuolar protein sorting-associated protein 13
 IPR026854  Vacuolar protein sorting-associated protein 13, N-terminal domain
 IPR031642  VPS13, repeated coiled region
 IPR031645  Vacuolar protein sorting-associated protein 13, C-terminal
 IPR031646  Vacuolar protein sorting-associated protein 13, second N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization ISO
 biological_processGO:1905090 negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0011886 increased circulating lipase level "elevated blood level of lipase in the blood, in particular the serum" [MGI:csmith]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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