ENSMUSG00000046230


Mus musculus

Features
Gene ID: ENSMUSG00000046230
  
Biological name :Vps13a
  
Synonyms : Q5H8C4 / vacuolar protein sorting 13A / Vps13a
  
Possible biological names infered from orthology : Q96RL7 / vacuolar protein sorting 13 homolog A
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 16615366
Gene end: 16780933
  
Corresponding Affymetrix probe sets: 10466441 (MoGene1.0st)   1430154_at (Mouse Genome 430 2.0 Array)   1431327_at (Mouse Genome 430 2.0 Array)   1440146_at (Mouse Genome 430 2.0 Array)   1440482_at (Mouse Genome 430 2.0 Array)   1457674_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152909
Ensembl peptide - ENSMUSP00000153129
Ensembl peptide - ENSMUSP00000068716
NCBI entrez gene - 271564     See in Manteia.
MGI - MGI:2444304
RefSeq - XM_006527126
RefSeq - XM_011247256
RefSeq - XM_017318216
RefSeq - NM_173028
RefSeq Peptide - NP_766616
swissprot - Q5H8C4
swissprot - A0A286YCC3
swissprot - A0A286YCT3
Ensembl - ENSMUSG00000046230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps13aENSDARG00000039225Danio rerio
 Q96RL7ENSG00000197969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BX70 / Vps13c / vacuolar protein sorting 13C / Q709C8* / vacuolar protein sorting 13 homolog C*ENSMUSG0000003528443
Vps13d / vacuolar protein sorting 13D / Q5THJ4* / vacuolar protein sorting 13 homolog D*ENSMUSG0000002022020
Q80TY5 / Vps13b / vacuolar protein sorting 13B / Q7Z7G8* / vacuolar protein sorting 13 homolog B*ENSMUSG0000003764614


Protein motifs (from Interpro)
Interpro ID Name
 IPR009543  Vacuolar protein sorting-associated protein 13, SHR-binding domain
 IPR015412  Autophagy-related, C-terminal
 IPR026847  Vacuolar protein sorting-associated protein 13
 IPR026854  Vacuolar protein sorting-associated protein 13, N-terminal domain
 IPR031642  VPS13, repeated coiled region
 IPR031645  Vacuolar protein sorting-associated protein 13, C-terminal
 IPR031646  Vacuolar protein sorting-associated protein 13, second N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035176 social behavior IMP
 cellular_componentGO:0031045 dense core granule IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0003242 loss of basal ganglia neurons "loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010068 decreased red blood cell distribution width "lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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