ENSMUSG00000035569


Mus musculus

Features
Gene ID: ENSMUSG00000035569
  
Biological name :Ankrd11
  
Synonyms : Ankrd11 / Ankyrin repeat domain-containing protein 11 / E9Q4F7
  
Possible biological names infered from orthology : ankyrin repeat domain 11 / Q6UB99
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122883822
Gene end: 123042277
  
Corresponding Affymetrix probe sets: 10582445 (MoGene1.0st)   10582458 (MoGene1.0st)   1435778_at (Mouse Genome 430 2.0 Array)   1436967_at (Mouse Genome 430 2.0 Array)   1437633_at (Mouse Genome 430 2.0 Array)   1454863_at (Mouse Genome 430 2.0 Array)   1456110_at (Mouse Genome 430 2.0 Array)   1458452_at (Mouse Genome 430 2.0 Array)   1460020_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095938
Ensembl peptide - ENSMUSP00000148645
Ensembl peptide - ENSMUSP00000148523
Ensembl peptide - ENSMUSP00000133977
Ensembl peptide - ENSMUSP00000095939
NCBI entrez gene - 77087     See in Manteia.
MGI - MGI:1924337
RefSeq - NM_001081379
RefSeq Peptide - NP_001074848
swissprot - A0A1D5RLV9
swissprot - E9Q4F8
swissprot - G3UY79
swissprot - E9Q4F7
swissprot - A0A1D5RM64
Ensembl - ENSMUSG00000035569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ankrd11ENSDARG00000051886Danio rerio
 ENSGALG00000006222Gallus gallus
 Q6UB99ENSG00000167522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ankrd12 / ankyrin repeat domain 12 / Q6UB98*ENSMUSG0000003464729
Ankrd31 / ankyrin repeat domain 31 / Q8N7Z5*ENSMUSG000001095616
Tonsl / tonsoku-like, DNA repair protein / Q96HA7*ENSMUSG000000593235
Bcor / Q8CGN4 / BCL-6 corepressor / Q6W2J9*ENSMUSG000000403634
A2AQH4 / Bcorl1 / BCL-6 corepressor-like protein 1 / Q5H9F3* / BCL6 corepressor like 1*ENSMUSG000000369594
Slf1 / Q8R3P9 / SMC5-SMC6 complex localization factor 1 / Q9BQI6*ENSMUSG000000215974
Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*ENSMUSG000000261964


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0060323 head morphogenesis IMP
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060348 bone development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000440 domed skull 
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000441 wide skull 
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003842 abnormal metopic suture morphology "malformation of the articulation of the frontal bone from the sagital suture to the root of the nose" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004380 short frontal bone "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004421 enlarged parietal bone "increased size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0010043 abnormal frontonasal suture morphology "any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030069 broad face "increased width of the upper and lower face" [MGI:anna]
Show

Allelic Composition: Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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