ENSMUSG00000040363


Mus musculus

Features
Gene ID: ENSMUSG00000040363
  
Biological name :Bcor
  
Synonyms : BCL-6 corepressor / Bcor / Q8CGN4
  
Possible biological names infered from orthology : Q6W2J9
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 12036740
Gene end: 12160355
  
Corresponding Affymetrix probe sets: 10603627 (MoGene1.0st)   1428773_s_at (Mouse Genome 430 2.0 Array)   1429438_at (Mouse Genome 430 2.0 Array)   1439509_at (Mouse Genome 430 2.0 Array)   1452910_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122829
Ensembl peptide - ENSMUSP00000048024
Ensembl peptide - ENSMUSP00000068618
Ensembl peptide - ENSMUSP00000111174
Ensembl peptide - ENSMUSP00000111175
Ensembl peptide - ENSMUSP00000116258
Ensembl peptide - ENSMUSP00000120046
NCBI entrez gene - 71458     See in Manteia.
MGI - MGI:1918708
RefSeq - XM_017318624
RefSeq - NM_001168321
RefSeq - NM_029510
RefSeq - NM_175044
RefSeq - NM_175045
RefSeq - NM_175046
RefSeq - XM_017318621
RefSeq - XM_017318622
RefSeq - XM_017318623
RefSeq Peptide - NP_778210
RefSeq Peptide - NP_001161793
RefSeq Peptide - NP_083786
RefSeq Peptide - NP_778211
RefSeq Peptide - NP_778209
swissprot - Q8CGN4
swissprot - F7BEN2
swissprot - F6XPR4
Ensembl - ENSMUSG00000040363
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcorENSDARG00000017798Danio rerio
 BCORENSGALG00000016245Gallus gallus
 BCORENSG00000183337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2AQH4 / Bcorl1 / BCL-6 corepressor-like protein 1 / Q5H9F3* / BCL6 corepressor like 1*ENSMUSG0000003695925
Ankrd31 / ankyrin repeat domain 31 / Q8N7Z5*ENSMUSG0000010956110
Tonsl / tonsoku-like, DNA repair protein / Q96HA7*ENSMUSG000000593238
Slf1 / Q8R3P9 / SMC5-SMC6 complex localization factor 1 / Q9BQI6*ENSMUSG000000215978
Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*ENSMUSG000000261967
E9Q4F7 / Ankrd11 / Ankyrin repeat domain-containing protein 11 / Q6UB99* / ankyrin repeat domain 11*ENSMUSG000000355697
Ankrd12 / ankyrin repeat domain 12 / Q6UB98*ENSMUSG000000346476


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR031628  BCL-6 corepressor, non-ankyrin-repeat domain
 IPR032365  BCL-6 corepressor, PCGF1 binding domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000415 negative regulation of histone H3-K36 methylation ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development ISO
 biological_processGO:0030502 negative regulation of bone mineralization ISO
 biological_processGO:0035518 histone H2A monoubiquitination ISO
 biological_processGO:0042476 odontogenesis ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0051572 negative regulation of histone H3-K4 methylation ISO
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0065001 specification of axis polarity ISO
 biological_processGO:0070171 negative regulation of tooth mineralization ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0031519 PcG protein complex ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0031072 heat shock protein binding ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcortm1Vjba/Y,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * CBA/Ca

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: BcorGt(XE541)Byg/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

Allelic Composition: BcorGt(XE541)Byg/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

Allelic Composition: BcorGt(XE541)Byg/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: NonoGt(P030B07)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: NonoGt(P030B07)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

Allelic Composition: BcorGt(XE541)Byg/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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