ENSMUSG00000035678


Mus musculus

Features
Gene ID: ENSMUSG00000035678
  
Biological name :Tnfsf9
  
Synonyms : P41274 / Tnfsf9 / tumor necrosis factor (ligand) superfamily, member 9
  
Possible biological names infered from orthology : P41273 / TNF superfamily member 9
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 57105385
Gene end: 57107757
  
Corresponding Affymetrix probe sets: 10446229 (MoGene1.0st)   1422924_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040412
NCBI entrez gene - 21950     See in Manteia.
MGI - MGI:1101058
RefSeq - NM_009404
RefSeq Peptide - NP_033430
swissprot - P41274
swissprot - Q3U1Z9
Ensembl - ENSMUSG00000035678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P41273ENSG00000125657Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045585 positive regulation of cytotoxic T cell differentiation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IPI


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028965 P20334 / Tnfrsf9 / tumor necrosis factor receptor superfamily, member 9 / Q07011* / TNF receptor superfamily member 9*  / reaction / complex
 ENSMUSG00000035678 P41274 / Tnfsf9 / tumor necrosis factor (ligand) superfamily, member 9 / P41273* / TNF superfamily member 9*  / complex






 

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