ENSMUSG00000037206


Mus musculus

Features
Gene ID: ENSMUSG00000037206
  
Biological name :Islr
  
Synonyms : Immunoglobulin superfamily containing leucine-rich repeat protein / Islr / Q6GU68
  
Possible biological names infered from orthology : immunoglobulin superfamily containing leucine rich repeat / O14498
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 58156268
Gene end: 58204306
  
Corresponding Affymetrix probe sets: 10594044 (MoGene1.0st)   1418450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150316
Ensembl peptide - ENSMUSP00000045142
Ensembl peptide - ENSMUSP00000126963
NCBI entrez gene - 26968     See in Manteia.
MGI - MGI:1349645
RefSeq - XM_011242750
RefSeq - NM_001195431
RefSeq - NM_012043
RefSeq - XM_006511204
RefSeq Peptide - NP_001182360
RefSeq Peptide - NP_036173
swissprot - A0A1L1STF4
swissprot - Q6GU68
swissprot - A0A146E664
Ensembl - ENSMUSG00000037206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 islr2ENSDARG00000051875Danio rerio
 ENSGALG00000021525Gallus gallus
 ISLR2ENSGALG00000029151Gallus gallus
 ISLRENSG00000129009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Islr2 / Q5RKR3 / Immunoglobulin superfamily containing leucine-rich repeat protein 2 / Q6UXK2* / immunoglobulin superfamily containing leucine rich repeat 2*ENSMUSG0000005124348
Lrit3 / W8DXL4 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 / Q3SXY7* / leucine rich repeat, Ig-like and transmembrane domains 3*ENSMUSG0000009386523
Lrit1 / Q8K099 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 / Q9P2V4* / leucine rich repeat, Ig-like and transmembrane domains 1*ENSMUSG0000004104422
Lrit2 / Q6PFC5 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 / A6NDA9* / leucine rich repeat, Ig-like and transmembrane domains 2*ENSMUSG0000004341818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0008951 long radius "increased length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0010924 abnormal osteoid morphology "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0010926 increased osteoid volume "increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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