ENSMUSG00000093865


Mus musculus

Features
Gene ID: ENSMUSG00000093865
  
Biological name :Lrit3
  
Synonyms : Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 / Lrit3 / W8DXL4
  
Possible biological names infered from orthology : leucine rich repeat, Ig-like and transmembrane domains 3 / Q3SXY7
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 129787881
Gene end: 129804030
  
Corresponding Affymetrix probe sets: 10502131 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000136912
Ensembl peptide - ENSMUSP00000140184
NCBI entrez gene - 242235     See in Manteia.
MGI - MGI:2685267
RefSeq - NM_001287224
RefSeq Peptide - NP_001274153
swissprot - J3QNQ8
swissprot - W8DXL4
Ensembl - ENSMUSG00000093865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrit3aENSDARG00000055463Danio rerio
 lrit3bENSDARG00000057054Danio rerio
 LRIT3ENSGALG00000026627Gallus gallus
 LRIT3ENSG00000183423Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrit1 / Q8K099 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 / Q9P2V4* / leucine rich repeat, Ig-like and transmembrane domains 1*ENSMUSG0000004104431
Islr2 / Q5RKR3 / Immunoglobulin superfamily containing leucine-rich repeat protein 2 / Q6UXK2* / immunoglobulin superfamily containing leucine rich repeat 2*ENSMUSG0000005124321
Lrit2 / Q6PFC5 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 / A6NDA9* / leucine rich repeat, Ig-like and transmembrane domains 2*ENSMUSG0000004341820
Islr / Q6GU68 / Immunoglobulin superfamily containing leucine-rich repeat protein / O14498* / immunoglobulin superfamily containing leucine rich repeat*ENSMUSG0000003720615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0012145 increased a wave amplitude "increase in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0012147 increased a wave implicit time "increase in the time from the onset of light stimulus to the peak of the a wave" [MGI:smb]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

 MP:0012150 increased b wave implicit time "increase in the time from the onset of light stimulus to the peak of the b wave" [MGI:smb]
Show

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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