ENSMUSG00000037386


Mus musculus

Features
Gene ID: ENSMUSG00000037386
  
Biological name :Rims2
  
Synonyms : Q9EQZ7 / Regulating synaptic membrane exocytosis protein 2 / Rims2
  
Possible biological names infered from orthology : Q9UQ26 / regulating synaptic membrane exocytosis 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 39198261
Gene end: 39684372
  
Corresponding Affymetrix probe sets: 10423855 (MoGene1.0st)   1422809_at (Mouse Genome 430 2.0 Array)   1432102_at (Mouse Genome 430 2.0 Array)   1436470_at (Mouse Genome 430 2.0 Array)   1443215_at (Mouse Genome 430 2.0 Array)   1450761_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154645
Ensembl peptide - ENSMUSP00000154153
Ensembl peptide - ENSMUSP00000154531
Ensembl peptide - ENSMUSP00000048719
Ensembl peptide - ENSMUSP00000080711
Ensembl peptide - ENSMUSP00000153868
NCBI entrez gene - 116838     See in Manteia.
MGI - MGI:2152972
RefSeq - XM_017316413
RefSeq - NM_001256382
RefSeq - NM_001256383
RefSeq - NM_001256384
RefSeq - NM_053271
RefSeq - XM_017316406
RefSeq - XM_017316407
RefSeq - XM_017316408
RefSeq - XM_017316409
RefSeq - XM_017316410
RefSeq - XM_017316411
RefSeq - XM_017316412
RefSeq - XM_006520343
RefSeq - XM_011245432
RefSeq - XM_011245434
RefSeq - XM_011245444
RefSeq - XM_017316369
RefSeq - XM_017316370
RefSeq - XM_017316371
RefSeq - XM_017316372
RefSeq - XM_017316373
RefSeq - XM_017316374
RefSeq - XM_017316375
RefSeq - XM_017316376
RefSeq - XM_017316377
RefSeq - XM_017316378
RefSeq - XM_017316379
RefSeq - XM_017316380
RefSeq - XM_017316381
RefSeq - XM_017316382
RefSeq - XM_017316383
RefSeq - XM_017316384
RefSeq - XM_017316385
RefSeq - XM_017316386
RefSeq - XM_017316387
RefSeq - XM_017316388
RefSeq - XM_017316389
RefSeq - XM_017316390
RefSeq - XM_017316391
RefSeq - XM_017316392
RefSeq - XM_017316393
RefSeq - XM_017316394
RefSeq - XM_017316395
RefSeq - XM_017316396
RefSeq - XM_017316397
RefSeq - XM_017316398
RefSeq - XM_017316399
RefSeq - XM_017316400
RefSeq - XM_017316401
RefSeq - XM_017316402
RefSeq - XM_017316403
RefSeq - XM_017316404
RefSeq - XM_017316405
RefSeq Peptide - NP_001243311
RefSeq Peptide - NP_001243312
RefSeq Peptide - NP_001243313
RefSeq Peptide - NP_444501
swissprot - Q0VF51
swissprot - Q9EQZ7
swissprot - D9HP81
Ensembl - ENSMUSG00000037386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rims2aENSDARG00000101606Danio rerio
 rims2bENSDARG00000102690Danio rerio
 RIMS2ENSGALG00000040256Gallus gallus
 RIMS2ENSG00000176406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rims1 / regulating synaptic membrane exocytosis 1 / Q86UR5*ENSMUSG0000004167049
Rims3 / Q80U57 / regulating synaptic membrane exocytosis 3 / Q9UJD0*ENSMUSG0000003289013
Rims4 / P60191 / Regulating synaptic membrane exocytosis protein 4 / Q9H426* / regulating synaptic membrane exocytosis 4*ENSMUSG0000003522610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001478  PDZ domain
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR030631  Regulating synaptic membrane exocytosis protein 2
 IPR035892  C2 domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0016082 synaptic vesicle priming IMP
 biological_processGO:0017156 calcium ion regulated exocytosis IDA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IEA
 biological_processGO:0061669 spontaneous neurotransmitter secretion IGI
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential IGI
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IBA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0060077 inhibitory synapse IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0044325 ion channel binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0010104 enlarged thoracic cage "increased size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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