ENSMUSG00000041670


Mus musculus

Features
Gene ID: ENSMUSG00000041670
  
Biological name :Rims1
  
Synonyms : regulating synaptic membrane exocytosis 1 / Rims1
  
Possible biological names infered from orthology : Q86UR5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A5
Gene start: 22286251
Gene end: 22805994
  
Corresponding Affymetrix probe sets: 10353479 (MoGene1.0st)   1435667_at (Mouse Genome 430 2.0 Array)   1438305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131808
Ensembl peptide - ENSMUSP00000151404
Ensembl peptide - ENSMUSP00000080259
Ensembl peptide - ENSMUSP00000110928
Ensembl peptide - ENSMUSP00000140963
Ensembl peptide - ENSMUSP00000095420
Ensembl peptide - ENSMUSP00000095419
Ensembl peptide - ENSMUSP00000095418
Ensembl peptide - ENSMUSP00000095417
NCBI entrez gene - 116837     See in Manteia.
MGI - MGI:2152971
RefSeq - NM_001012624
RefSeq - NM_053270
RefSeq - NM_183018
RefSeq - NM_001012623
RefSeq - NM_001012625
RefSeq Peptide - NP_001012643
RefSeq Peptide - NP_001012642
RefSeq Peptide - NP_001012641
RefSeq Peptide - NP_898839
RefSeq Peptide - NP_444500
swissprot - Q7TPL9
swissprot - A0A087WSA4
swissprot - A0A1W2P6S9
swissprot - E9PWP6
swissprot - F6TZK4
swissprot - F6VBR4
swissprot - F6VBT9
swissprot - F6VBV0
swissprot - F6Y0S3
Ensembl - ENSMUSG00000041670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rims1aENSDARG00000074680Danio rerio
 rims1bENSDARG00000078902Danio rerio
 RIMS1ENSGALG00000015944Gallus gallus
 RIMS1ENSG00000079841Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rims2 / Q9EQZ7 / Regulating synaptic membrane exocytosis protein 2 / Q9UQ26* / regulating synaptic membrane exocytosis 2*ENSMUSG0000003738654
Rims3 / Q80U57 / regulating synaptic membrane exocytosis 3 / Q9UJD0*ENSMUSG0000003289014
Rims4 / P60191 / Regulating synaptic membrane exocytosis protein 4 / Q9H426* / regulating synaptic membrane exocytosis 4*ENSMUSG0000003522611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001478  PDZ domain
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR030630  Regulating synaptic membrane exocytosis protein 1
 IPR035892  C2 domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
Show

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002918 abnormal paired-pulse facilitation "defects in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0002921 abnormal post-tetanic potential "defects in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Rims1tm3Sud/Rims1tm3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010104 enlarged thoracic cage "increased size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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