ENSMUSG00000037685


Mus musculus

Features
Gene ID: ENSMUSG00000037685
  
Biological name :Atp8a1
  
Synonyms : Atp8a1 / P70704 / Phospholipid-transporting ATPase IA
  
Possible biological names infered from orthology : ATPase phospholipid transporting 8A1 / Q9Y2Q0
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 67618140
Gene end: 67847434
  
Corresponding Affymetrix probe sets: 10530319 (MoGene1.0st)   1423597_at (Mouse Genome 430 2.0 Array)   1423598_at (Mouse Genome 430 2.0 Array)   1433827_at (Mouse Genome 430 2.0 Array)   1433828_at (Mouse Genome 430 2.0 Array)   1433965_at (Mouse Genome 430 2.0 Array)   1444355_at (Mouse Genome 430 2.0 Array)   1454728_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118379
Ensembl peptide - ENSMUSP00000109282
Ensembl peptide - ENSMUSP00000121630
Ensembl peptide - ENSMUSP00000144465
Ensembl peptide - ENSMUSP00000042215
Ensembl peptide - ENSMUSP00000072738
Ensembl peptide - ENSMUSP00000109281
NCBI entrez gene - 11980     See in Manteia.
MGI - MGI:1330848
RefSeq - XM_017320627
RefSeq - NM_009727
RefSeq - XM_006503703
RefSeq - XM_006503704
RefSeq - XM_006503705
RefSeq - XM_011240698
RefSeq - XM_017320623
RefSeq - XM_017320624
RefSeq - XM_017320625
RefSeq - XM_017320626
RefSeq - NM_001038999
RefSeq - NM_001284345
RefSeq Peptide - NP_001034088
RefSeq Peptide - NP_001271274
RefSeq Peptide - NP_033857
swissprot - P70704
swissprot - E9Q4J5
swissprot - A0A0J9YV34
swissprot - Q3U9N5
swissprot - F6Q8P7
swissprot - A0A0M3HEP7
Ensembl - ENSMUSG00000037685
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP8A1ENSDARG00000114495Danio rerio
 ATP8A1ENSGALG00000014236Gallus gallus
 ATP8A1ENSG00000124406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp8a2 / P98200 / Phospholipid-transporting ATPase IB / Q9NTI2* / ATPase phospholipid transporting 8A2*ENSMUSG0000002198367
Atp8b1 / Q148W0 / Phospholipid-transporting ATPase IC / O43520* / ATPase phospholipid transporting 8B1*ENSMUSG0000003952940
Atp8b4 / ATPase, class I, type 8B, member 4 / Q8TF62* / ATPase phospholipid transporting 8B4 (putative)*ENSMUSG0000006013139
Atp8b2 / P98199 / Phospholipid-transporting ATPase ID / P98198* / ATPase phospholipid transporting 8B2*ENSMUSG0000006067139
A3FIN4 / Atp8b5 / Phospholipid-transporting ATPase FetA ENSMUSG0000002845737
Atp10a / O54827 / Probable phospholipid-transporting ATPase VA / O60312* / ATPase phospholipid transporting 10A (putative)*ENSMUSG0000002532435
Atp11b / ATPase, class VI, type 11B / Q9Y2G3* / ATPase phospholipid transporting 11B (putative)*ENSMUSG0000003740035
Atp11c / Q9QZW0 / Phospholipid-transporting ATPase 11C / Q8NB49* / ATPase phospholipid transporting 11C*ENSMUSG0000006294932
Atp11a / P98197 / Probable phospholipid-transporting ATPase IH / P98196* / ATPase phospholipid transporting 11A*ENSMUSG0000003144132


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006539  P-type ATPase, subfamily IV
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR032630  P-type ATPase, C-terminal
 IPR032631  P-type ATPase, N-terminal
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0048194 Golgi vesicle budding IBA
 biological_processGO:0061092 positive regulation of phospholipid translocation IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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