ENSMUSG00000062949


Mus musculus

Features
Gene ID: ENSMUSG00000062949
  
Biological name :Atp11c
  
Synonyms : Atp11c / Phospholipid-transporting ATPase 11C / Q9QZW0
  
Possible biological names infered from orthology : ATPase phospholipid transporting 11C / Q8NB49
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A6
Gene start: 60223290
Gene end: 60592698
  
Corresponding Affymetrix probe sets: 10604799 (MoGene1.0st)   1442367_at (Mouse Genome 430 2.0 Array)   1452496_at (Mouse Genome 430 2.0 Array)   1455083_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033480
Ensembl peptide - ENSMUSP00000099066
Ensembl peptide - ENSMUSP00000119320
NCBI entrez gene - 320940     See in Manteia.
MGI - MGI:1859661
RefSeq - XM_011247616
RefSeq - XM_006528094
RefSeq - XM_006528095
RefSeq - XM_006528096
RefSeq - XM_006528097
RefSeq - XM_011247615
RefSeq - NM_001001798
RefSeq - NM_001037863
RefSeq - XM_006528090
RefSeq - XM_006528091
RefSeq - XM_006528093
RefSeq Peptide - NP_001001798
RefSeq Peptide - NP_001032952
swissprot - F6Q8D3
swissprot - Q9QZW0
swissprot - E9QKK8
Ensembl - ENSMUSG00000062949
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp11cENSDARG00000036442Danio rerio
 ATP11CENSGALG00000006623Gallus gallus
 ATP11CENSG00000101974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp11a / P98197 / Probable phospholipid-transporting ATPase IH / P98196* / ATPase phospholipid transporting 11A*ENSMUSG0000003144162
Atp11b / ATPase, class VI, type 11B / Q9Y2G3* / ATPase phospholipid transporting 11B (putative)*ENSMUSG0000003740053
Atp8b4 / ATPase, class I, type 8B, member 4 / Q8TF62* / ATPase phospholipid transporting 8B4 (putative)*ENSMUSG0000006013134
Atp8b2 / P98199 / Phospholipid-transporting ATPase ID / P98198* / ATPase phospholipid transporting 8B2*ENSMUSG0000006067133
Atp8b1 / Q148W0 / Phospholipid-transporting ATPase IC / O43520* / ATPase phospholipid transporting 8B1*ENSMUSG0000003952933
A3FIN4 / Atp8b5 / Phospholipid-transporting ATPase FetA ENSMUSG0000002845733
Atp8a2 / P98200 / Phospholipid-transporting ATPase IB / Q9NTI2* / ATPase phospholipid transporting 8A2*ENSMUSG0000002198333
Atp8a1 / P70704 / Phospholipid-transporting ATPase IA / Q9Y2Q0* / ATPase phospholipid transporting 8A1*ENSMUSG0000003768533
Atp10a / O54827 / Probable phospholipid-transporting ATPase VA / O60312* / ATPase phospholipid transporting 10A (putative)*ENSMUSG0000002532431


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006539  P-type ATPase, subfamily IV
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030363  Phospholipid-transporting ATPase IG
 IPR032630  P-type ATPase, C-terminal
 IPR032631  P-type ATPase, N-terminal
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002329 pre-B cell differentiation IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0045332 phospholipid translocation IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T/tbtm
Genetic Background: involves: C57BL/6 * MOL-NIS

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Atp11cm1Btlr/Atp11cm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp11cm1Btlr/Y,Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu

Allelic Composition: Atp11cm1Btlr/Atp11cm2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp11cm2Btlr/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp11cm1Btlr/Y,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

Allelic Composition: Atp11cambr/Y,Tg(H2-Ea-Il7)10Rhdr/0
Genetic Background: involves: C57BL/6 * C57BL/6JApb * DBA/2

Allelic Composition: Atp11cambr/Y,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6JApb

Allelic Composition: Atp11cm2Anu/Y
Genetic Background: C57BL/6JAnu-Atp11cm2Anu/AnuApb

Allelic Composition: Atp11cm2Btlr/Atp11cm2Btlr
Genetic Background: involves: C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp11cm1Btlr/Y,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008175 absent follicular B cells "absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Atp11cm1Btlr/Y,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

Allelic Composition: Atp11cambr/Y,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6JApb

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

Allelic Composition: Atp11cambr/Y,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6JApb

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Atp11cm1Btlr/Y,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Atp11cambr/Y
Genetic Background: C57BL/6-Atp11cambr

Allelic Composition: Atp11cambr/Y,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6JApb

Allelic Composition: Atp11cambr/Y,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6JApb

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010228 decreased transitional stage T3 B cell number "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
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Allelic Composition: Ptch1wig/Ptch1wig
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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