ENSG00000124406


Homo sapiens

Features
Gene ID: ENSG00000124406
  
Biological name :ATP8A1
  
Synonyms : ATP8A1 / ATPase phospholipid transporting 8A1 / Q9Y2Q0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p13
Gene start: 42408373
Gene end: 42657105
  
Corresponding Affymetrix probe sets: 1569773_at (Human Genome U133 Plus 2.0 Array)   210192_at (Human Genome U133 Plus 2.0 Array)   213106_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427295
Ensembl peptide - ENSP00000426636
Ensembl peptide - ENSP00000426935
Ensembl peptide - ENSP00000264449
Ensembl peptide - ENSP00000371084
Ensembl peptide - ENSP00000421164
Ensembl peptide - ENSP00000426495
NCBI entrez gene - 10396     See in Manteia.
OMIM - 609542
RefSeq - XM_017007647
RefSeq - NM_001105529
RefSeq - NM_006095
RefSeq - XM_005248043
RefSeq - XM_011513615
RefSeq - XM_011513616
RefSeq - XM_011513618
RefSeq - XM_017007645
RefSeq - XM_017007646
RefSeq Peptide - NP_006086
RefSeq Peptide - NP_001098999
swissprot - H0YAJ4
swissprot - Q9Y2Q0
swissprot - H0Y8I6
swissprot - H0YAA1
swissprot - Q4G1C1
swissprot - H0YAF4
Ensembl - ENSG00000124406
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP8A1ENSDARG00000114495Danio rerio
 ATP8A1ENSGALG00000014236Gallus gallus
 Atp8a1ENSMUSG00000037685Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP8A2 / Q9NTI2 / ATPase phospholipid transporting 8A2ENSG0000013293268
ATP8B1 / O43520 / ATPase phospholipid transporting 8B1ENSG0000008192340
ATP8B2 / P98198 / ATPase phospholipid transporting 8B2ENSG0000014351540
ATP8B4 / Q8TF62 / ATPase phospholipid transporting 8B4 (putative)ENSG0000010404339
ATP10D / Q9P241 / ATPase phospholipid transporting 10D (putative)ENSG0000014524635
ATP8B3 / O60423 / ATPase phospholipid transporting 8B3ENSG0000013027035
ATP10A / O60312 / ATPase phospholipid transporting 10A (putative)ENSG0000020619035
ATP11B / Q9Y2G3 / ATPase phospholipid transporting 11B (putative)ENSG0000005806334
ATP11A / P98196 / ATPase phospholipid transporting 11AENSG0000006865033
ATP11C / Q8NB49 / ATPase phospholipid transporting 11CENSG0000010197432


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006539  P-type ATPase, subfamily IV
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR032630  P-type ATPase, C-terminal
 IPR032631  P-type ATPase, N-terminal
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0048194 Golgi vesicle budding IBA
 biological_processGO:0061092 positive regulation of phospholipid translocation IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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