ENSG00000068650


Homo sapiens

Features
Gene ID: ENSG00000068650
  
Biological name :ATP11A
  
Synonyms : ATP11A / ATPase phospholipid transporting 11A / P98196
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 112690329
Gene end: 112887168
  
Corresponding Affymetrix probe sets: 213582_at (Human Genome U133 Plus 2.0 Array)   215842_s_at (Human Genome U133 Plus 2.0 Array)   216488_s_at (Human Genome U133 Plus 2.0 Array)   230875_s_at (Human Genome U133 Plus 2.0 Array)   241603_at (Human Genome U133 Plus 2.0 Array)   241604_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410824
Ensembl peptide - ENSP00000402575
Ensembl peptide - ENSP00000420387
Ensembl peptide - ENSP00000479392
Ensembl peptide - ENSP00000420696
Ensembl peptide - ENSP00000364781
Ensembl peptide - ENSP00000364796
Ensembl peptide - ENSP00000396374
NCBI entrez gene - 23250     See in Manteia.
OMIM - 605868
RefSeq - XM_017020492
RefSeq - XM_005268299
RefSeq - XM_005268300
RefSeq - XM_005268301
RefSeq - XM_005268303
RefSeq - XM_005268305
RefSeq - XM_005268306
RefSeq - XM_011537480
RefSeq - XM_017020490
RefSeq - XM_017020491
RefSeq - NM_015205
RefSeq - NM_032189
RefSeq Peptide - NP_056020
RefSeq Peptide - NP_115565
swissprot - H0Y547
swissprot - H0Y624
swissprot - E9PEJ6
swissprot - P98196
swissprot - A0A087WVE8
swissprot - H0Y8F0
swissprot - A2A3G9
Ensembl - ENSG00000068650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp11aENSDARG00000008413Danio rerio
 ATP11AENSGALG00000041644Gallus gallus
 Atp11aENSMUSG00000031441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP11C / Q8NB49 / ATPase phospholipid transporting 11CENSG0000010197463
ATP11B / Q9Y2G3 / ATPase phospholipid transporting 11B (putative)ENSG0000005806358
ATP8A2 / Q9NTI2 / ATPase phospholipid transporting 8A2ENSG0000013293235
ATP8B2 / P98198 / ATPase phospholipid transporting 8B2ENSG0000014351534
ATP8A1 / Q9Y2Q0 / ATPase phospholipid transporting 8A1ENSG0000012440634
ATP8B1 / O43520 / ATPase phospholipid transporting 8B1ENSG0000008192333
ATP10D / Q9P241 / ATPase phospholipid transporting 10D (putative)ENSG0000014524633
ATP8B4 / Q8TF62 / ATPase phospholipid transporting 8B4 (putative)ENSG0000010404333
ATP10A / O60312 / ATPase phospholipid transporting 10A (putative)ENSG0000020619032
ATP8B3 / O60423 / ATPase phospholipid transporting 8B3ENSG0000013027030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006539  P-type ATPase, subfamily IV
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030361  Probable phospholipid-transporting ATPase IH
 IPR032630  P-type ATPase, C-terminal
 IPR032631  P-type ATPase, N-terminal
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045332 phospholipid translocation IEA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0002020 Gastroesophageal reflux 
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 HP:0002110 Bronchiectasis 
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 HP:0002206 Pulmonary fibrosis 
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 HP:0002875 Exertional dyspnea 
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 HP:0010444 Pulmonary insufficiency "The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole." [HPO:curators]
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 HP:0012735 Cough "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." [HPO:probinson]
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 HP:0025175 Honeycomb lung "Extensive interstitial fibrosis with alveolar disruption and bronchiolectasis." []
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 HP:0025179 Ground-glass opacification "A descriptive term that is applied to computer tomography imaging and that refers to a hazy area of increased attenuation in the lung with preserved bronchial and vascular markings." []
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 HP:0025390 Reticular pattern on pulmonary HRCT "On pulmonary high-resolution computed tomography, reticular pattern is characterised by innumerable interlacing shadows suggesting a mesh." [PMID:23247773]
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 HP:0030830 Rales "Abnormal breath sounds characterized by discontinuous clicking or rattling." [UToronto:chum]
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 HP:0100759 Clubbing of fingers "Terminal broadening of the fingers (distal phalanges of the fingers)." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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