ENSMUSG00000038156


Mus musculus

Features
Gene ID: ENSMUSG00000038156
  
Biological name :Spon1
  
Synonyms : Q8VCC9 / Spon1 / spondin 1, (f-spondin) extracellular matrix protein
  
Possible biological names infered from orthology : Q9HCB6 / spondin 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 113765998
Gene end: 114043370
  
Corresponding Affymetrix probe sets: 10556509 (MoGene1.0st)   1424415_s_at (Mouse Genome 430 2.0 Array)   1441226_at (Mouse Genome 430 2.0 Array)   1442613_at (Mouse Genome 430 2.0 Array)   1451342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041157
Ensembl peptide - ENSMUSP00000081746
NCBI entrez gene - 233744     See in Manteia.
MGI - MGI:2385287
RefSeq - NM_145584
RefSeq Peptide - NP_663559
swissprot - Q3UYD7
swissprot - Q8VCC9
Ensembl - ENSMUSG00000038156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spon1aENSDARG00000010029Danio rerio
 SPON1ENSGALG00000038775Gallus gallus
 SPON1ENSG00000262655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spon2 / Q8BMS2 / Spondin-2 / Q9BUD6*ENSMUSG0000003737914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR002861  Reeler domain
 IPR009465  Spondin, N-terminal
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0013623 increased femur compact bone thickness "increased width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

 MP:0013631 decreased bone trabecular spacing "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Prickle1tm1Asw/Prickle1tm1.2Asw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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